Ptbp1 - polypyrimidine tract binding protein 1 Gene

Also Known as Ptb; PTB1; Pybp; Pybp1; Pybp2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29497

Summary

Enables nucleic acid binding activity and single-stranded DNA endodeoxyribonuclease activity. Involved in several processes, including mRNA metabolic process; positive regulation of cellular component organization; and positive regulation of gene expression. Located in cytoplasm; neuron projection terminus; and nucleus. Orthologous to human PTBP1 (polypyrimidine tract binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ptbp1 Products (2)

mRNA Protein Name
NM_001271057.1 NP_001257986.1 polypyrimidine tract-binding protein 1 isoform a
NM_022516.5 NP_071961.2 polypyrimidine tract-binding protein 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA binding IDA
IDA: Inferred from direct assay
19273590 RGD
enables regulatory region RNA binding IDA
IDA: Inferred from direct assay
23511971 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
1561080 RGD
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
1561080 RGD
enables single-stranded DNA endodeoxyribonuclease activity IDA
IDA: Inferred from direct assay
12269805 RGD
Biological Process GO Annotation Evidence References Source
involved in 3'-UTR-mediated mRNA stabilization IDA
IDA: Inferred from direct assay
11696543 RGD
involved in cardiac ventricle development IEP
IEP: Inferred from expression pattern
19590510 RGD
involved in mRNA processing IMP
IMP: Inferred from mutant phenotype
16177139 RGD
involved in nuclear-transcribed mRNA catabolic process IMP
IMP: Inferred from mutant phenotype
15039777 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
15039777 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
17400307 RGD
involved in positive regulation of secretory granule organization IMP
IMP: Inferred from mutant phenotype
15039777 RGD
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
19273590 RGD
Cellular Component GO Annotation Evidence References Source
located in neuron projection terminus IDA
IDA: Inferred from direct assay
17400307 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polypyrimidine tract-binding protein 1

  • heterogeneous nuclear ribonucleoprotein I

  • hnRNP I

  • pyrimidine binding protein 1

  • pyrimidine binding protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5960 PTBP1-RNA-binding inhibitor P6 TFA 98.59% Unkown
HY-167832 PT109 99.20% Unkown
HY-RS11351 PTBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17773 Ptbp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24240 Ptbp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptbp1 NCBI NCBI:5725