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STN1 - STN1 subunit of CST complex Gene

Also Known as AAF44; OBFC1; AAF-44; RPA-32; bA541N10.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79991

About STN1

Cytogenetic location: 10q24.33 Genomic coordinates (GRCh38): 10:103,877,569-103,918,184 (from NCBI)

This gene has 20 transcripts (splice variants), 203 orthologues, 2 paralogues and is associated with 4 phenotypes. Ubiquitous expression in testis (RPKM 3.8), lung (RPKM 3.8) and 25 other tissues.

Summary

OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]

STN1 Products (1)

mRNA	Protein	Name
NM_024928.5	NP_079204.2	CST complex subunit STN1

STN1 Protein Structure

tRNA_anti-codon

STN1_2

0
100
200
300
368 a.a.

Protein Preferred Names	Protein Names
CST complex subunit STN1	STN1, CST complex subunit

STN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STN1	Q9H668	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
Intra	STN1	Q9H668	TPP1	Homo sapiens	O14773-1	Y2H	22763445
Intra	STN1	Q9H668	TEN1	Homo sapiens	Q86WV5	Anti Tag CoIP	33961781
Intra	STN1	Q9H668	TEN1	Homo sapiens	Q86WV5	Y2H	19854130
Intra	STN1	Q9H668	TEN1	Homo sapiens	Q86WV5	Anti Tag CoIP	28514442
Intra	STN1	Q9H668	CTC1	Homo sapiens	Q2NKJ3	Anti Tag CoIP	33961781
Intra	STN1	Q9H668	CTC1	Homo sapiens	Q2NKJ3	Anti Tag CoIP	28514442
Intra	STN1	Q9H668	CTC1	Homo sapiens	Q2NKJ3	Y2H	19854130
Intra	STN1	Q9H668	CTC1	Homo sapiens	Q2NKJ3	Anti Tag CoIP	19854130
Intra	STN1	Q9H668	ACD	Homo sapiens	Q96AP0	BiFC	19648609
Intra	STN1	Q9H668	ACD	Homo sapiens	Q96AP0	Anti Tag CoIP	19648609
Intra	STN1	Q9H668	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	STN1	Q9H668	LDLRAP1	Homo sapiens	Q5SW96	Anti Tag CoIP	33961781
Intra	STN1	Q9H668	LDLRAP1	Homo sapiens	Q5SW96	Validated Y2H	25416956
Intra	STN1	Q9H668	LDLRAP1	Homo sapiens	Q5SW96	Anti Tag CoIP	28514442
Intra	STN1	Q9H668	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STN1 Proteins

Cat. No.	상품명	Accession	Purity
HY-P70981	OBFC1 Protein, Human (His)	AAH17400.1 (M1-F368)	≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Cerebroretinal Microangiopathy With Calcifications And Cysts 2	CRMCC2
Cerebroretinal Microangiopathy With Calcifications And Cysts 1	Coats Plus Syndrome Cerebroretinal Microangiopathy With Calcifications And Cysts Crmcc CRMCC1 Microangiopathy, Cerebroretinal, With Calcifications And Cysts Cerebral Small Vessel Diseases
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Premature Aging	Syndrome With Premature-Aging
Portal Hypertension	Hypertension, Portal Hypertension Portal Pht - [Portal Hypertension] Portal Htn
Pancytopenia
Spasticity
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 Melanoma, Malignant CMM1 Melanoma, Cutaneous Malignant Cmm Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS13948	STN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13952	STON1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20340	Stn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26848	Stn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	STN1	VGNC	VGNC:78219
Canis familiaris	STN1	VGNC	VGNC:46930
Felis catus	STN1	VGNC	VGNC:65791
Bos taurus	STN1	VGNC	VGNC:35408
Rattus norvegicus	STN1	RGD	RGD:1305637
Mus musculus	STN1	MGD	MGI:1915581
Others	STN1	NCBI