OBFC1 Protein, Human (His)
OBFC1 Protein, Human (His) is the recombinant human-derived OBFC1 protein, expressed by E. coli, with N-6*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
OBFC1 Protein, Human (His) is the recombinant human-derived OBFC1 protein, expressed by E. coli, with N-6*His labeled tag.
Background
Components of the CST complex are thought to be special replicators that promote DNA replication under natural replication disorder conditions such as replication stress or telomere duplex. The CST complex binds high-affinity single-stranded DNA in a sequence-independent manner, while the isolated subunits bind low-affinity DNA on their own. The CST complex protects telomeres from DNA degradation, inhibits telomerase and participates in telomere length homeostasis. The CST complex can bind to the newly synthesized 3 'suspension of telomerase and terminate the action of telomerase associated with the ACD: POT1 complex, thereby interfering with its telomerase-stimulating activity. The CST complex is also thought to be involved in the filling synthesis of the telomere C chain. The expression of OBFC1 gene is associated with tumor[1][2][3][4][5][6].
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His
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Accession
AAH17400.1 (M1-F368)
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Molecular Construction
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N-term
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6*His
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OBFC1 (M1-F368)
Accession # AAH17400.1 -
C-term
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Protein Length
Full Length
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Synonyms
STN1; STN1, CST Complex Subunit; Prev. OBFC1; Replication Protein A 32 KDa Subunit; Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 1; Alpha Accessory Factor 44; Suppressor Of Cdc Thirteen Homolog; RPA-32; CST Complex Subunit STN1; CRMCC2;
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AA Sequence
MQPGSSRCEEETPSLLWGLDPVFLAFAKLYIRDILDMKESRQVPGVFLYNGHPIKQVDVLGTVIGVRERDAFYSYGVDDSTGVINCICWKKLNTESVSAAPSAARELSLTSQLKKLQETIEQKTKIEIGDTIRVRGSIRTYREEREIHATAYYKVDDPVWNIQIARMLELPTIYRKVYDQPFHSSALEKEEALSNPGALDLPSLTSLLSEKAKEFLMENRVQSFYQQELEMVESLLSLANQPVIHSACSDQVNFKKDTTSKAIHSIFKNAIQLLQEKGLVFQKDDGFDNLYYVTREDKDLHRKIHRIIQQDCQKPNHMEKGCHFLHILACARLSIRPGLSEAVLQQVLELLEDQSDIVSTMEHYYTAF
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Predicted Molecular Mass
44.3 kDa
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Molecular Weight
Approximately 44 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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