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TEN1 - TEN1 subunit of CST complex Gene

Also Known as C17orf106

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 100134934

About TEN1

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,979,240-76,000,586 (from NCBI)

This gene has 5 transcripts (splice variants) and 182 orthologues. Ubiquitous expression in small intestine (RPKM 13.6), fat (RPKM 12.7) and 25 other tissues.

Summary

C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1; MIM 613128) and CTC1 (C17ORF68; MIM 613129) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]

TEN1 Products (1)

mRNA	Protein	Name
NM_001113324.3	NP_001106795.2	CST complex subunit TEN1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19854130	GOA
enables telomeric DNA binding	IDA IDA: Inferred from direct assay	19854130	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of telomere maintenance via telomerase	IDA IDA: Inferred from direct assay	22763445	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CST complex	IDA IDA: Inferred from direct assay	19854130	GOA
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	19854130	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19854130	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEN1 Protein Structure

Ten1_2

0
100
123 a.a.

Protein Preferred Names	Protein Names
CST complex subunit TEN1	TEN1 telomerase capping complex subunit homolog

TEN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TEN1	Q86WV5	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	TEN1	Q86WV5	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	TEN1	Q86WV5	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	TEN1	Q86WV5	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	TEN1	Q86WV5	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	TEN1	Q86WV5	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	TEN1	Q86WV5	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	TEN1	Q86WV5	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	TEN1	Q86WV5	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	TEN1	Q86WV5	CTC1	Homo sapiens	Q2NKJ3	Anti Tag CoIP	33961781
Intra	TEN1	Q86WV5	CTC1	Homo sapiens	Q2NKJ3	Anti Tag CoIP	28514442
Intra	TEN1	Q86WV5	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	TEN1	Q86WV5	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	TEN1	Q86WV5	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	TEN1	Q86WV5	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
Intra	TEN1	Q86WV5	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
Intra	TEN1	Q86WV5	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
Intra	TEN1	Q86WV5	RAN	Homo sapiens	P62826	Y2H Array	32814053
Intra	TEN1	Q86WV5	RAN	Homo sapiens	P62826	Validated Y2H	32814053
Intra	TEN1	Q86WV5	RAN	Homo sapiens	P62826	Y2H Pooling	32814053
Intra	TEN1	Q86WV5	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	TEN1	Q86WV5	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	TEN1	Q86WV5	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	TEN1	Q86WV5	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	TEN1	Q86WV5	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	TEN1	Q86WV5	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	TEN1	Q86WV5	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	TEN1	Q86WV5	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	TEN1	Q86WV5	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	TEN1	Q86WV5	PRPF40A	Homo sapiens	O75400-2	Validated Y2H	32814053
Intra	TEN1	Q86WV5	PRPF40A	Homo sapiens	O75400-2	Y2H Array	32814053
Intra	TEN1	Q86WV5	PRPF40A	Homo sapiens	O75400-2	Y2H Pooling	32814053
Intra	TEN1	Q86WV5	CASP6	Homo sapiens	P55212	Validated Y2H	32814053
Intra	TEN1	Q86WV5	CASP6	Homo sapiens	P55212	Y2H Array	32814053
Intra	TEN1	Q86WV5	CASP6	Homo sapiens	P55212	Y2H Pooling	32814053
Intra	TEN1	Q86WV5	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	32814053
Intra	TEN1	Q86WV5	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32814053
Intra	TEN1	Q86WV5	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32814053
Intra	TEN1	Q86WV5	STN1	Homo sapiens	Q9H668	Y2H Prey Pooling	32296183
Intra	TEN1	Q86WV5	STN1	Homo sapiens	Q9H668	Pull Down	22763445
Intra	TEN1	Q86WV5	STN1	Homo sapiens	Q9H668	Validated Y2H	32296183
Intra	TEN1	Q86WV5	STN1	Homo sapiens	Q9H668	Anti Tag CoIP	19854130
Intra	TEN1	Q86WV5	STN1	Homo sapiens	Q9H668	Y2H Array	32296183
Intra	TEN1	Q86WV5	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	TEN1	Q86WV5	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	TEN1	Q86WV5	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	TEN1	Q86WV5	PRPH	Homo sapiens	P41219	Validated Y2H	32814053
Intra	TEN1	Q86WV5	PRPH	Homo sapiens	P41219	Y2H Array	32814053
Intra	TEN1	Q86WV5	PRPH	Homo sapiens	P41219	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Dyskeratosis Congenita, Autosomal Recessive 6	DKCB6 Autosomal Recessive Dyskeratosis Congenita 6 Dyskeratosis Congenita, Autosomal Recessive, 6 Dyskeratosis Congenita, Autosomal Recessive, Type 6
Dyskeratosis Congenita, Autosomal Recessive 1	DKCB1 Autosomal Recessive Dyskeratosis Congenita 1 Dyskeratosis Congenita, Autosomal Recessive, 1 Dyskeratosis Congenita, Autosomal Recessive, Type 1
Dyskeratosis Congenita, Autosomal Recessive 3	DKCB3 Autosomal Recessive Dyskeratosis Congenita 3 Dyskeratosis Congenita, Autosomal Recessive, 3 Dyskeratosis Congenita, Autosomal Recessive, Type 3
Immunodeficiency 26	Severe Combined Immunodeficiency Due To Dna-Pkcs Deficiency Scid Due To Dna-Pkcs Deficiency Imd26 Immunodeficiency 26, With Or Without Neurologic Abnormalities
Retinal Telangiectasia
Revesz Syndrome	Exudative Retinopathy With Bone Marrow Failure DKCA5 Dyskeratosis Congenita, Autosomal Dominant 5 Dyskeratosis Congenita With Bilateral Exudative Retinopathy Retinopathy-Anemia-Central Nervous System Anomalies Syndrome Revesz-Debuse Syndrome Dyskeratosis Congenita, Autosomal Dominant, 5 Revesz Debuse Syndrome
Glioblastoma Mesenchymal Subtype
Coats Disease	Exudative Retinopathy Retinal Telangiectasis Coats' Disease Leber Miliary Aneurysm Coats' Syndrome Congenital Retinal Telangiectasia
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 Melanoma, Malignant CMM1 Melanoma, Cutaneous Malignant Cmm Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14361	TEN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14362	TENM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W392413	Glutathione monoethyl ester	Inhibitor	/	Unkown
HY-RS22854	Tenm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TEN1	RGD	RGD:1311078
Bos taurus	TEN1	VGNC	VGNC:54498
Canis familiaris	TEN1	VGNC	VGNC:54372
Mus musculus	TEN1	MGD	MGI:1916785
Others	TEN1	NCBI