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Cat. No.: HY-145317

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LRRK2-IN-2

LRRK2-IN-2 (compoubd 22) is a potent, selective, orally active and brain-penetrant inhibitor LRRK2, with IC₅₀ of <0.6 nM. LRRK2-IN-2 can be used for the research of Parkinson's disease.

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CAS No.: 2641059-19-8
화학식: C₂₃H₂₃Cl₂F₃N₆O₂
분자량:543.37

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

LRRK2-IN-2 Chemical Structure

CAS No.: 2641059-19-8

사이즈

가격

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

LRRK2-IN-2 (compoubd 22) is a potent, selective, orally active and brain-penetrant inhibitor LRRK2, with IC₅₀ of <0.6 nM. LRRK2-IN-2 can be used for the research of Parkinson's disease^[1].

IC₅₀ & Target

IC50: <0.6 nM (LRRK2)^[1]

Chemical Information

CAS No. 2641059-19-8
분자량 543.37
화학식 C₂₃H₂₃Cl₂F₃N₆O₂
SMILES

FC1([C@@H](N2C(Cl)=C(C=N2)NC3=NC4=C(C=C(C([C@H]5[C@@H](CN([C@H]6[C@H](COC6)O)CC5)F)=C4)Cl)C=N3)C1)F
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Keylor MH, et, al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022 Jan 13;65(1):838-856. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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