O-GlcNAcase-IN-2
O-GlcNAcase-IN-2 (compound 81) is an orally effective, blood-brain barrier-permeable OGA inhibitor (IC50=4.93 nM). O-GlcNAcase-IN-2 can increase the O-GlcNAcylation level of proteins and phosphorylation of tau (p-Ser199, p-Thr205 and p-Ser396) in the OA-damaged SH-SY5Y cell model. O-GlcNAcase-IN-2 can also improve cognitive impairment in APP/PS1 mice and has potential anti-Alzheimer's disease (AD) effects.
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- 화학식: C22H26N4OS
- 분자량:394.53
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
IC50: 4.93 nM (OGA)[1]
Chemical Information
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분자량 394.53
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화학식 C22H26N4OS
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SMILES
CC(NC(S1)=NC=C1CN(CC2)CCC2C#CC3=CC(CCCN4)=C4C=C3)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
O-GlcNAcase-IN-2 Related Classifications
HY-161953 Related Classifications
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