Four new phenanthrenes from Monomeria barbata Lindl

  • Fitoterapia. 2010 Dec;81(8):992-7. doi: 10.1016/j.fitote.2010.06.019.
Minghui Yang  1 ,  Le Cai ,  Zhigang Tai ,  Xianghui Zeng ,  Zhongtao Ding
Affiliations
  • 1. Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
PMID: 20600684 DOI: 10.1016/j.fitote.2010.06.019
Abstract

Three biphenanthrene compounds (1-3) and a triphenanthrene compound (4), together with six known biphenanthrene compounds (5-10), were isolated from the tubers of Monomeria barbata Lindl. Their structures were elucidated on the basis of extensive spectroscopic analysis (1D-, 2D-NMR, and HR-ESI-MS). These four new compounds were tested in vitro for the cytotoxic activity against liver carcinoma (HepG-2), promyelocytic leukaemia (HL60), ovarian carcinoma (Skov-3) and epidermoid carcinoma (A431) Cancer cell lines and the antioxidant activity in DPPH radical scavenging. Compounds 1-4 exhibited significant cytotoxic activity against HepG-2 and HL60 cell lines, and potent antioxidant activity in DPPH radical scavenging.

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