STING agonist-48
STING agonist-48 is a potent STING agonist that exhibits STING-dependent activity in vitro (EC50 = 4.02 μM). STING agonist-48 prefers to bind with the transmembrane domain (TMD) over the cytosolic cyclic dinucleotide (CDN) domain. STING agonist-48 shows adjuvant efficacy, enhancing IgG and Th1/Th2 cytokine responses in humanized STING mice. STING agonist-48 can be used for the study of inflammation-related diseases.
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- CAS No.: 3027712-31-5
- 화학식: C23H16F4N2O3S
- 분자량:476.44
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
STING agonist-48 (Compound 7k) (6.25-50 μM, 24 h) induces a dose-dependent increase in luciferase activity in THF-ISRE IRF3 cells, demonstrating a strong STING activation effect, but it does not induce luciferase activity in THF-ISRE STING-/- cells, where activity was completely lost, and it maintains a dose-dependent increase in THF-ISRE TRIF/MAVS-/- cells[1].
STING agonist-48 does not cause any change in the thermal stability of the STING cytoplasmic domain[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male and female C57BL/6 humanized STING (huSTING; 6-12 weeks) mice were intramuscularly immunized and boosted (at a two-week interval) with 50 μL of either detergent-split A/Victoria/210/2009 (H3N2, A/Vic)[1].
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Dosage:20 μg
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Administration:I.m., 0 day, 14 days
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Result:Serum IgG1, IgG2, and total IgG titers were significantly increased in mice.
Increased secretion of IFN-γ, IL-4, and IL-5 from spleen cells.
Chemical Information
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CAS No. 3027712-31-5
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분자량 476.44
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화학식 C23H16F4N2O3S
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SMILES
O=C(C1=CC=C(N2CC3=C(O)C=CC=C3F)C(SCC2=O)=C1)NCC4=C(F)C=C(F)C=C4F
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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