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Cat. No.: HY-18911

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Type-II-IN-1

Type-II-IN-1 (Compound 3) is a type II spleen tyrosine kinase (Syk) inhibitor with an IC₅₀ of 2.1 nM. Type-II-IN-1 can bind to the DFG-out conformation of Syk. Type-II-IN-1 can be used for the research of immunology, such as asthma.

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CAS No.: 1419299-81-2
화학식: C₂₉H₂₂F₃N₅O₂
분자량:529.51

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Type-II-IN-1 Chemical Structure

CAS No.: 1419299-81-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

Chemical Information

CAS No. 1419299-81-2
분자량 529.51
화학식 C₂₉H₂₂F₃N₅O₂
SMILES

O=C(C1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(C)C(C3=CC4=C(N(C)C3=O)N=C(NC5=CC=CC=C5)N=C4)=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lovering F, et al. Identification of type-II inhibitors using kinase structures[J]. Chemical biology & drug design, 2012, 80(5): 657-664. [Content Brief]

Calculators

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Concentration Concentration

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Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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