Z-Pro-Pro-aldehyde-dimethyl acetal
Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 170116-63-9
- 화학식: C20H28N2O5
- 분자량:376.45
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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PREP 12 nM (IC50) |
Pro-{Pro-Aldehyde-dimethyl acetal}
P-{Pro-Aldehyde-dimethyl acetal}
Chemical Information
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CAS No. 170116-63-9
-
분자량 376.45
-
화학식 C20H28N2O5
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Robin S B Williams, et al. A common mechanism of action for three mood-stabilizing drugs. Nature. 2002 May 16;417(6886):292-5. [Content Brief]
[2]. Andis Klegeris, et al. Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP‐1 cell neurotoxicity. Glia. 2008 Apr 15;56(6):675-85. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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