Lortalamine
Lortalamine (LM 1404) is a selective norepinephrine transporter inhibitor with an IC50 of <1 nM. Lortalamine is a non-tricyclic antidepressant. Lortalamine antagonises Reserpine (HY-N0480)-induced ptosis and hypothermia. Lortalamine inhibits norepinephrine uptake.
For research use only. We do not sell to patients.
- CAS No.: 70384-91-7
- Formula: C15H17ClN2O2
- Molecular Weight:292.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: <1 nM (norepinephrine transporter)[1]
Chemical Information
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CAS No. 70384-91-7
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Molecular Weight 292.76
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Formula C15H17ClN2O2
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SMILES
O=C1N[C@@]23[C@@](CN(CC3)C)([H])[C@](C1)([H])C4=CC(Cl)=CC=C4O2
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Synonyms
LM 1404
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lin KS, et al. Synthesis and C-11 labeling of three potent norepinephrine transporter selective ligands ((R)-nisoxetine, lortalamine, and oxaprotiline) for comparative PET studies in baboons. Bioorg Med Chem. 2005 Aug 1;13(15):4658-66. [Content Brief]
[2]. Depin JC, et al. Pharmacology of lortalamine, a new potent non-tricyclic antidepressant. Arzneimittelforschung. 1985;35(11):1655-62. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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