Thiosemicarbazide
Based on 1 publication(s) in Google Scholar
Thiosemicarbazide is a vitamin B6 antagonist with anti-acne activity. Thiosemicarbazide is also a well-known source in the synthesis of heterocycles, and its derivatives have potential anticancer activity. Thiosemicarbazide (TSC: HL1) reacts with metal salts, urea (U), to prepare Co(II) and Cu(I) metal complexes. Thiosemicarbazide is also used in the fields of media communications and optical storage, and in the spectrophotometric detection of metals.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 79-19-6
- Formula: CH5N3S
- Molecular Weight:91.14
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Thiosemicarbazide
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Biological Activity
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MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 79-19-6
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Appearance Solid
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Molecular Weight 91.14
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Formula CH5N3S
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Color Off-white to yellow
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SMILES
NNC(N)=S
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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PLoS Pathog
Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase. [Abstract]2026 Jan 26;22(1):e1013903. PMID: 41587213
Solvent & Solubility
DMSO : 125 mg/mL (1371.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (269 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Portuguese - PT (479 KB)
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Handling Instructions (2659 KB)
References
[1]. Yamashita J. Susceptibility to thiosemicarbazide (an antagonist of vitamin B6), and phylogenetic and ontogenetic development of brain. J Nutr Sci Vitaminol (Tokyo). 1974;20(2):113-9. [Content Brief]
[2]. Kozyra P, et al. Potential Anticancer Agents against Melanoma Cells Based on an As-Synthesized Thiosemicarbazide Derivative. Biomolecules. 2022 Jan 18;12(2):151. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 10.9721 mL | 54.8607 mL | 109.7213 mL | 274.3033 mL |
| 5 mM | 2.1944 mL | 10.9721 mL | 21.9443 mL | 54.8607 mL | |
| 10 mM | 1.0972 mL | 5.4861 mL | 10.9721 mL | 27.4303 mL | |
| 15 mM | 0.7315 mL | 3.6574 mL | 7.3148 mL | 18.2869 mL | |
| 20 mM | 0.5486 mL | 2.7430 mL | 5.4861 mL | 13.7152 mL | |
| 25 mM | 0.4389 mL | 2.1944 mL | 4.3889 mL | 10.9721 mL | |
| 30 mM | 0.3657 mL | 1.8287 mL | 3.6574 mL | 9.1434 mL | |
| 40 mM | 0.2743 mL | 1.3715 mL | 2.7430 mL | 6.8576 mL | |
| 50 mM | 0.2194 mL | 1.0972 mL | 2.1944 mL | 5.4861 mL | |
| 60 mM | 0.1829 mL | 0.9143 mL | 1.8287 mL | 4.5717 mL | |
| 80 mM | 0.1372 mL | 0.6858 mL | 1.3715 mL | 3.4288 mL | |
| 100 mM | 0.1097 mL | 0.5486 mL | 1.0972 mL | 2.7430 mL |
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