Lycium schweinfurthii: new secondary metabolites and their cytotoxic activities

  • Nat Prod Res. 2022 Oct;36(20):5134-5141. doi: 10.1080/14786419.2021.1922902.
Ahmed Elbermawi  1  2 ,  Ahmed F Halim  1 ,  El-Sayed S Mansour  1 ,  Kadria F Ahmad  1 ,  Marwa Elsbaey  1  2 ,  Ahmed Ashour  1  2 ,  Yhiya Amen  1  2 ,  Mohammed M El-Gamil  3 ,  Miyamoto Tomofumi  4 ,  Kuniyoshi Shimizu  2
Affiliations
  • 1. Department of Pharmacognosy Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
  • 2. Division of Systematic Forest and Forest Products Sciences, Department of Agro-Environmental Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.
  • 3. Department of Toxic and Narcotic Drugs, Forensic Medicine, Mansoura Laboratory, Medico-legal Organization, Ministry of Justice, Mansoura, Egypt.
  • 4. Department of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
PMID: 34180314 DOI: 10.1080/14786419.2021.1922902
Abstract

Two new compounds, 11S-methoxy-11,12-dihydro phytuberin (2) and 9S-methoxy-benzocyclononan-7-one (6), together with twenty-six known ones were isolated from Lycium schweinfurthii (Solanaceae). Their planar structure was established by extensive spectroscopic analyses. The absolute configuration of compound 6 was determined by time dependent density functional theory calculations (TDDFT). The cytotoxic potential of the isolates was assessed in cultured skin Cancer (G-361) and colon Cancer (HCT-116 and CaCo-2) cell lines. Certain Flavonoids showed the highest cytotoxic activity, with IC50 values ranging from 7.1 to 63.3 µM; meanwhile 5-flurouracil showed IC50 values ranging from 62.4 to >100 µM. All compounds showed minimal toxicity towards normal cells from skin (NHDF-4) and colon (CCD-841), indicating their potential selectivity and safety as cytotoxic candidates.

Keywords
CaCo-2; G-361; HCT-116; Lycium schweinfurthii; Solanaceae; cytotoxicity.
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