1. Recombinant Proteins
  2. CD Antigens Receptor Proteins
  3. Stem Cell CD Proteins Platelet CD Proteins
  4. TPO-R/CD110
  5. C-MPL Protein, Cynomolgus (HEK293, His)

C-MPL Protein, Cynomolgus (HEK293, His)

Cat. No.: HY-P700977
COA Handling Instructions

C-MPL protein is a key member of the type I cytokine receptor family and is essential for mediating cellular responses to various cytokines. Its research enhances our understanding of cell signaling, providing potential applications for therapeutic intervention in hematopoietic disorders and immune disorders. C-MPL Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived C-MPL protein, expressed by HEK293 , with C-His labeled tag. The total length of C-MPL Protein, Cynomolgus (HEK293, His) is 468 a.a., with molecular weight of 60-70 kDa.

For research use only. We do not sell to patients.

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Description

C-MPL protein is a key member of the type I cytokine receptor family and is essential for mediating cellular responses to various cytokines. Its research enhances our understanding of cell signaling, providing potential applications for therapeutic intervention in hematopoietic disorders and immune disorders. C-MPL Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived C-MPL protein, expressed by HEK293 , with C-His labeled tag. The total length of C-MPL Protein, Cynomolgus (HEK293, His) is 468 a.a., with molecular weight of 60-70 kDa.

Background

The C-MPL Protein is a pivotal member of the type I cytokine receptor family, specifically falling under the Type 1 subfamily, underlining its crucial role in mediating cellular responses to various cytokines. As part of this receptor family, C-MPL likely shares conserved structural and functional features with related receptors, emphasizing its involvement in transducing signals from specific type I cytokines. The classification within the type I cytokine receptor family underscores its specific designation within the broader context of cell signaling, providing insights into its unique contributions to hematopoiesis and immune regulation. The study of C-MPL contributes to our understanding of its role in physiological processes, offering potential applications in therapeutic interventions for conditions related to hematopoietic disorders and immune dysregulation. Further exploration of C-MPL's role holds promise for enhancing our knowledge of its contributions to both normal cellular function and pathological conditions.

Species

Cynomolgus

Source

HEK293

Tag

C-His

Accession

A0A2K5UGC7 (Q22-T489)

Gene ID

/

Molecular Construction
N-term
C-MPL (Q22-T489)
Accession # A0A2K5UGC7
His
C-term
Synonyms
TPO-R; CD110; MPL; c-Mpl; MPLV; K12
Molecular Weight

60-70 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

C-MPL Protein, Cynomolgus (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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C-MPL Protein, Cynomolgus (HEK293, His)
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HY-P700977
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