LIME1 - Lck interacting transmembrane adaptor 1 Gene

Also Known as LIME; dJ583P15.4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54923

About LIME1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,735,701-63,739,103 (from NCBI)

This gene has 10 transcripts (splice variants), 76 orthologues and 2 paralogues. Broad expression in kidney (RPKM 23.8), liver (RPKM 18.5) and 21 other tissues.

Summary

This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]

LIME1 Products (3)

mRNA Protein Name
NM_001305654.2 NP_001292583.1 lck-interacting transmembrane adapter 1 isoform 2 precursor
NM_001305655.2 NP_001292584.1 lck-interacting transmembrane adapter 1 isoform 2 precursor
NM_017806.4 NP_060276.2 lck-interacting transmembrane adapter 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIME1 Protein Structure

LIME1

LIME1: Lck-interacting transmembrane adapter 1 (27 - 259)

  • 0
  • 100
  • 200
  • 295 a.a.
Protein Preferred Names Protein Names

lck-interacting transmembrane adapter 1

  • lck-interacting membrane protein

LIME1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LIME1 Q9H400 PNPO Homo sapiens Q9NVS9
Validated Y2H
32296183
Intra
LIME1 Q9H400 AIG1 Homo sapiens Q9NVV5-2
Validated Y2H
32296183
Intra
LIME1 Q9H400 NDRG4 Homo sapiens Q9ULP0-2
Validated Y2H
32296183
Intra
LIME1 Q9H400 LPAR3 Homo sapiens Q9UBY5
Validated Y2H
32296183
Intra
LIME1 Q9H400 MAN2B2 Homo sapiens Q9Y2E5
Validated Y2H
32296183
Intra
LIME1 Q9H400 ARFGAP3 Homo sapiens Q9NP61
Validated Y2H
32296183
Intra
LIME1 Q9H400 TRAF7 Homo sapiens Q6Q0C0
Anti Tag CoIP
33961781
Intra
LIME1 Q9H400 CLN6 Homo sapiens Q9NWW5
Validated Y2H
32296183
Intra
LIME1 Q9H400 CIAO2A Homo sapiens Q9H5X1
Validated Y2H
32296183
Intra
LIME1 Q9H400 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cerebral Palsy

  • Infantile Cerebral Palsy

  • Mixed Cerebral Palsy

  • Palsy Cerebral

  • Palsy, Cerebral

  • Cerebral Palsy, Mixed
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N16520 Kaempferol 3-O-β-D-glucopyranoside 6′′-(3-hydroxy-3-methylglutarate) / Unkown
HY-RS07661 LIME1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W749649 Neomenthoglycol / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LIME1 RGD RGD:1562795
Mus musculus LIME1 MGD MGI:1919949
Others LIME1 NCBI