LIN7B - lin-7 homolog B, crumbs cell polarity complex component Gene

Also Known as MALS2; VELI2; LIN-7B; MALS-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64130

About LIN7B

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,114,370-49,118,460 (from NCBI)

This gene has 7 transcripts (splice variants), 181 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 4.4), testis (RPKM 3.8) and 25 other tissues.

Summary

Enables protein domain specific binding activity. Predicted to be involved in maintenance of epithelial cell apical/basal polarity; neurotransmitter secretion; and protein localization to basolateral plasma membrane. Predicted to be located in plasma membrane. Predicted to be part of MPP7-DLG1-LIN7 complex. Predicted to be active in basolateral plasma membrane; cell-cell junction; and synapse. [provided by Alliance of Genome Resources, Apr 2022]

LIN7B Products (2)

mRNA Protein Name
NM_001308419.2 NP_001295348.1 protein lin-7 homolog B isoform 2
NM_022165.3 NP_071448.1 protein lin-7 homolog B isoform 1

LIN7B Protein Structure

L27

L27: L27 domain (13 - 67)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (94 - 172)

  • 0
  • 100
  • 207 a.a.
Protein Preferred Names Protein Names

protein lin-7 homolog B

  • hLin7B

LIN7B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LIN7B Q9HAP6 CASK Homo sapiens O14936-4
Y2H Prey Pooling
32296183
Intra
LIN7B Q9HAP6 CASK Homo sapiens O14936-4
Y2H Array
32296183
Intra
LIN7B Q9HAP6 MPP2 Homo sapiens Q14168-4
Y2H Prey Pooling
32296183
Intra
LIN7B Q9HAP6 MPP2 Homo sapiens Q14168-4
Y2H Array
32296183
Intra
LIN7B Q9HAP6 PALS1 Homo sapiens Q8N3R9
Anti Tag CoIP
33961781
Intra
LIN7B Q9HAP6 MPP7 Homo sapiens Q5T2T1
Anti Tag CoIP
33961781
Intra
LIN7B Q9HAP6 MPP7 Homo sapiens Q5T2T1
Y2H Prey Pooling
32296183
Intra
LIN7B Q9HAP6 MPP7 Homo sapiens Q5T2T1
Y2H Array
32296183
Intra
LIN7B Q9HAP6 PALS2 Homo sapiens Q9NZW5
Y2H Prey Pooling
32296183
Intra
LIN7B Q9HAP6 PALS2 Homo sapiens Q9NZW5
Validated Y2H
32296183
Intra
LIN7B Q9HAP6 PALS2 Homo sapiens Q9NZW5
Y2H Array
32296183
Intra
LIN7B Q9HAP6 PALS2 Homo sapiens Q9NZW5
Anti Tag CoIP
33961781
Intra
LIN7B Q9HAP6 MPP3 Homo sapiens Q13368
Y2H Prey Pooling
32296183
Intra
LIN7B Q9HAP6 MPP3 Homo sapiens Q13368
Y2H Array
32296183
Intra
LIN7B Q9HAP6 MPP3 Homo sapiens Q13368
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Huntington Disease

  • Huntington'S Disease

  • Huntington Chorea

  • Huntington'S Chorea

  • HD

  • Huntington Chronic Progressive Hereditary Chorea

  • Juvenile Huntington Disease

  • Chronic Progressive Chorea

  • Chronic Progressive Hereditary Chorea

  • Hc - [Huntington Chorea]

  • Hereditary Chorea

  • Progressive Hereditary Chorea
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07677 LIN7B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LIN7B VGNC VGNC:53735
Macaca mulatta LIN7B VGNC VGNC:74069
Mus musculus LIN7B MGD MGI:1330858
Rattus norvegicus LIN7B RGD RGD:620730
Bos taurus LIN7B VGNC VGNC:30896
Felis catus LIN7B VGNC VGNC:63234
Others LIN7B NCBI