HKDC1 - hexokinase domain containing 1 Gene

Also Known as RP92

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80201

About HKDC1

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:69,220,332-69,267,552 (from NCBI)

This gene has 3 transcripts (splice variants), 178 orthologues, 4 paralogues and is associated with 2 phenotypes. Biased expression in duodenum (RPKM 22.5), small intestine (RPKM 21.3) and 6 other tissues.

Summary

This gene encodes a member of the Hexokinase protein family. The encoded protein is involved in glucose metabolism, and reduced expression may be associated with gestational diabetes mellitus. High expression of this gene may also be associated with poor prognosis in hepatocarcinoma. [provided by RefSeq, Sep 2016]

HKDC1 Products (1)

mRNA	Protein	Name
NM_025130.4	NP_079406.4	hexokinase HKDC1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables glucokinase activity	IDA IDA: Inferred from direct assay	30517626	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in glucose 6-phosphate metabolic process	IDA IDA: Inferred from direct assay	30517626	GOA
involved in intracellular glucose homeostasis	IDA IDA: Inferred from direct assay	30517626	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	30085091	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	30517626	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HKDC1 Protein Structure

Hexokinase_1

Hexokinase_2

Hexokinase_1

Hexokinase_2

0
200
400
600
800
917 a.a.

Protein Preferred Names	Protein Names
hexokinase HKDC1	hexokinase domain-containing protein 1

HKDC1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83243	HKDC1 Antibody (YA2988)	WB, IP	Human
HY-P83243A	HKDC1 Antibody (YA2988)(PBS only)	WB, IP	Human

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 92	RP92 Retinitis Pigmentosa, Type 92
Orofacial Cleft 1	OFC1 Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 1 Orofacial Cleft, Nonsyndromic Ofc Cleft Lip/Palate, Nonsyndromic Orofacial Cleft-1 Nonsyndromic Cleft Lip With Or Without Cleft Palate 1 Nonsyndromic Cleft Lip Palate Otofaciocervical Syndrome 1
Gestational Diabetes	Gestational Diabetes Mellitus GDM Diabetes Mellitus Arising In Pregnancy Maternal Gestational Diabetes Mellitus Diabetes Mellitus, Gestational Diabetes Mellitus, Pregnancy Related Diabetes, Pregnancy-Induced Diabetes Gestational Diabetes, Gestational Diabetes Of Pregnancy Gdm - [Gestational Diabetes Mellitus] Gestational Diabetes Mellitus Nos Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium
Retinitis Pigmentosa 73	RP73 Retinitis Pigmentosa, Type 73
Diabetes Mellitus	Diabetes
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06195	HKDC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19441	Hkdc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25933	Hkdc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HKDC1	VGNC	VGNC:41701
Macaca mulatta	HKDC1	VGNC	VGNC:73432
Mus musculus	HKDC1	MGD	MGI:2384910
Rattus norvegicus	HKDC1	RGD	RGD:2321830
Bos taurus	HKDC1	VGNC	VGNC:29867