6 Results for "

ERG11

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "ERG11" in MCE Product Catalog:

HDAC/HSP90-IN-3
HDAC/HSP90-IN-3
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Cat. No.: HY-144694
CAS No.: 2700035-54-5
Target:  

HSP HDAC Fungal

Research Areas:  

Infection

HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC50 values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1 .
HSP90-IN-9
HSP90-IN-9
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Cat. No.: HY-145814
CAS No.: 2765247-36-5
Target:  

HSP Fungal

Research Areas:  

Infection

HSP90-IN-9 is a potent and selective HSP90 inhibitor. HSP90-IN-9 displays a fungicidal effect in a dose-dependent manner. HSP90-IN-9 inhibits fungal biofilm formation and fungal morphological changes after being combined with FLC. HSP90-IN-9 recovers FLC resistance by down-regulating the expression of related genes (ERG11, CDR1 and CDR2) .
CYP51-IN-20
CYP51-IN-20
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Cat. No.: HY-159585
Target:  

Cytochrome P450 Fungal

Research Areas:  

Infection

CYP51-IN-20 (compound 5b) is an inhibitor of CYP51 and has antifungal activity. CYP51-IN-20 has a significant inhibitory effect on Candida albicans ATCC 10231, downregulates ERG11 (Cyp51) gene expression, and significantly reduces the yeast-to-hyphae morphological transition. CYP51-IN-20 can synergize with Voriconazole (HY-76200) to occupy the entire CYP51 binding site and exert a synergistic inhibitory effect in the Glechoma moth model .
ERG11 Protein, Saccharomyces cerevisiae (GST)
ERG11 Protein, Saccharomyces cerevisiae (GST)
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Cat. No.: HY-P72165
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ERG11; CYP51; YHR007CLanosterol 14-alpha demethylase; EC 1.14.14.154; CYPLI; Cytochrome P450 51; Cytochrome P450-14DM; Cytochrome P450-LIA1; Sterol 14-alpha demethylase
Species:  
Others
Source:  
E. coli
Antibacterial agent 230
Antibacterial agent 230
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Cat. No.: HY-161822
CAS No.: 3049368-26-2
Target:  

Bacterial

Research Areas:  

Infection

Antibacterial agent 230 (compound 10) is an effective Antifungal agent. The MIC value of antibacterial agent 230 against fluconazole-resistant fungi is 2.0 ~ 16.0 μg/mL .
F2F-202
F2F-202
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Cat. No.: HY-184165
Target:  

HDAC Fungal

Research Areas:  

Infection

F2F-202 is a selective HDAC6 inhibitor with an IC50 of 7.1 nM, exhibiting high selectivity toward HDAC1. F2F-202 does not directly bind to or inhibit the Hda1 protease activity of Candida albicans itself, but reduces the mRNA transcription level of the Hda1 gene. When combined with Voriconazole (HY-76200), F2F-202 decreases the yeast-hypha transition rate of azole-resistant Candida albicans and impairs the antioxidant response of azole-resistant Candida albicans. F2F-202 can be used in studies related to azole-resistant Candida albicans infections .
Assay Types