2 Results for "

largazole

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "largazole" in MCE Product Catalog:

Largazole
Largazole
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Cat. No.: HY-13906
CAS No.: 1009815-87-5
Synonyms: (+)-largazole
Category:  

Natural Products Microorganisms

Target:  

HDAC

Largazole ((+)-Largazole) is a potent, selective, orally active and brain-penetrant class I HDAC inhibitor found in marine cyanobacteria. Largazole shows an IC50 of 0.07 nM for HDAC2. Largazole releases its active form Largazole thiol (HY-170890) after hydrolysis. Largazole has a strong inhibitory effect on SF-268, SF-295 and SH-SY5Y cells, with IC50 values of 62, 68 and 102 nM respectively Largazole can upregulate the tumor suppressor gene Pax6 to inhibit the proliferation, invasion and colony formation of glioblastoma cells. Largazole can significantly upregulated brain-derived neurotrophic factor BDNF, neuronal transcription factor Pax6, and μ-opioid receptor gene Oprm1. Largazole exerts antitumor and neuroprotective effects. Largazole can be used for researches of Glioblastoma and Alzheimer’s disease .
Largazole thiol
Largazole thiol
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Cat. No.: HY-170890
CAS No.: 1132667-11-8
Target:  

HDAC

Research Areas:  

Neurological Disease Cancer

Largazole thiol, the active form of Largazole (HY-13906), is a potent, selective and brain-penetrant class I HDAC inhibitor. Largazole thiol. Largazole thiol exerts antitumor and neuroprotective effects. Largazole thiol can be used for research of Glioblastoma .
Assay Types