KPNA1 - karyopherin subunit alpha 1 Gene

Also Known as RCH2; SRP1; IPOA5; NPI-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3836

About KPNA1

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,421,902-122,514,939 (from NCBI)

This gene has 10 transcripts (splice variants), 199 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 10.0), testis (RPKM 7.9) and 25 other tissues.

Summary

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin Ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

KPNA1 Products (1)

mRNA Protein Name
NM_002264.4 NP_002255.3 importin subunit alpha-5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear import signal receptor activity IDA
IDA: Inferred from direct assay
7892216 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10523667 GOA
Biological Process GO Annotation Evidence References Source
involved in NLS-bearing protein import into nucleus IDA
IDA: Inferred from direct assay
7892216 GOA
Cellular Component GO Annotation Evidence References Source
part of NLS-dependent protein nuclear import complex IPI
IPI: Inferred from physical interaction
10523667 GOA
is active in cytosol IDA
IDA: Inferred from direct assay
7892216 GOA
is active in nucleoplasm IDA
IDA: Inferred from direct assay
7892216 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KPNA1 Protein Structure

IBB

IBB: Importin beta binding domain (3 - 94)

Arm

Arm: Armadillo/beta-catenin-like repeat (115 - 156)

Arm

Arm: Armadillo/beta-catenin-like repeat (158 - 197)

Arm

Arm: Armadillo/beta-catenin-like repeat (203 - 241)

Arm

Arm: Armadillo/beta-catenin-like repeat (254 - 283)

Arm

Arm: Armadillo/beta-catenin-like repeat (286 - 324)

Arm

Arm: Armadillo/beta-catenin-like repeat (330 - 367)

Arm

Arm: Armadillo/beta-catenin-like repeat (369 - 408)

Arm

Arm: Armadillo/beta-catenin-like repeat (412 - 451)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 538 a.a.
Protein Preferred Names Protein Names

importin subunit alpha-5

  • RAG cohort protein 2

KPNA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KPNA1 P52294 STAT1 Homo sapiens P42224
Anti Tag CoIP
17596301
Intra
KPNA1 P52294 NUP50 Homo sapiens Q9UKX7
Y2H Prey Pooling
25416956
Intra
KPNA1 P52294 NUP50 Homo sapiens Q9UKX7
Validated Y2H
25416956
Intra
KPNA1 P52294 NUP50 Homo sapiens Q9UKX7
Anti Tag CoIP
26496610
Intra
KPNA1 P52294 NUP50 Homo sapiens Q9UKX7
Validated Y2H
32296183
Intra
KPNA1 P52294 NUP50 Homo sapiens Q9UKX7
Anti Tag CoIP
35271311
Intra
KPNA1 P52294 KPNB1 Homo sapiens Q14974
Anti Tag CoIP
17596301
Intra
KPNA1 P52294 KPNB1 Homo sapiens Q14974
Anti Tag CoIP
35271311
Intra
KPNA1 P52294 NMNAT1 Homo sapiens Q9HAN9
Validated Y2H
32296183
Intra
KPNA1 P52294 MACROD1 Homo sapiens Q9BQ69
Validated Y2H
32296183
Intra
KPNA1 P52294 POLR3C Homo sapiens Q9BUI4
Validated Y2H
32296183
Intra
KPNA1 P52294 POLR3C Homo sapiens Q9BUI4
Anti Tag CoIP
33961781
Intra
KPNA1 P52294 CLK4 Homo sapiens Q9HAZ1
Validated Y2H
25416956
Intra
KPNA1 P52294 SF1 Homo sapiens Q15637
Y2H Fragment Pooling
26420826
Intra
KPNA1 P52294 ANP32B Homo sapiens Q92688
Y2H
21988832
Intra
KPNA1 P52294 ANP32B Homo sapiens Q92688
Confocal
21988832
Intra
KPNA1 P52294 ANP32B Homo sapiens Q92688
Validated Y2H
25416956
Intra
KPNA1 P52294 ANP32B Homo sapiens Q92688
Validated Y2H
32296183
Intra
KPNA1 P52294 ANP32B Homo sapiens Q92688
Anti Tag CoIP
35271311
Intra
KPNA1 P52294 ANP32B Homo sapiens Q92688
Y2H Prey Pooling
25416956
Intra
KPNA1 P52294 GRM1 Homo sapiens Q13255
Anti Tag CoIP
19084525
Intra
KPNA1 P52294 GRM1 Homo sapiens Q13255
Anti Bait CoIP
19084525
Intra
KPNA1 P52294 LMNB1 Homo sapiens P20700
Anti Tag CoIP
26496610
Cross
KPNA1 P52294 PB2 Influenza A virus B4URF7
Pull Down
21994455
Cross
KPNA1 P52294 PB2 Influenza A virus P31345
X-Ray Diffraction
17310249
Cross
KPNA1 P52294 PB2 Influenza A virus P31345
GMS
17310249
Cross
KPNA1 P52294 Q9WMX2-PRO_0000037548 Hepatitis C virus Q9WMX2-PRO_0000037548
Y2H Prey Pooling
18985028
Cross
KPNA1 P52294 Q9WMX2-PRO_0000037548 Hepatitis C virus Q9WMX2-PRO_0000037548
Pull Down
18985028
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Venezuelan Equine Encephalitis

  • Venezuelan Equine Fever

  • Venezuelan Equine Encephalomyelitis

  • Encephalitis Venezuelan Equine

  • Encephalomyelitis, Venezuelan Equine

  • Venezuelan Encephalitis

  • Disorder Due To Venezuelan Equine Encephalitis Virus

  • Venezuelan Equine Encephalitis Virus Infection

  • Venezuelan Equine Encephalomyelitis Virus Disease
Encephalitis

  • Mumps Encephalitis

  • Mumps Meningoencephalitis

  • Herpes Simplex Neuroinvasion

  • Herpetic Encephalitis

  • Herpetic Encephalopathy

  • Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

  • Encephalitis Due To Herpesviridae

  • Encephalitis Due To Herpesvirus

  • Herpes Encephalitis

  • Herpesviral Encephalitis

  • Herpes Simplex Encephalitis

  • Hsv - [Herpes Simplex Virus] Encephalitis

  • Herpes Virus Encephalitis

  • Simian B Disease

  • Simian B Disorder

  • Encephalitis Nec

  • Idiopathic Encephalitis
Influenza

  • Flu

  • Influenza With Non-Respiratory Manifestation

  • Influenza With Other Manifestations

  • Influenza, Human

  • Influenza, Susceptibility To

  • Seasonal Influenza, Virus Identified
Plica Syndrome

  • Synovitis
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS22602 Kpna1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07415 KPNA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29118 Kpna1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KPNA1 RGD RGD:735064
Felis catus KPNA1 VGNC VGNC:102766
Mus musculus KPNA1 MGD MGI:103560
Bos taurus KPNA1 VGNC VGNC:30700
Macaca mulatta KPNA1 VGNC VGNC:74199
Canis familiaris KPNA1 VGNC VGNC:42500
Others KPNA1 NCBI