SSR2 - signal sequence receptor subunit 2 Gene

Also Known as TLAP; HSD25; TRAPB; TRAP-BETA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6746

About SSR2

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:156,009,048-156,020,951 (from NCBI)

This gene has 18 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in ovary (RPKM 141.0), adrenal (RPKM 105.9) and 25 other tissues.

Summary

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. [provided by RefSeq, Jul 2008]

SSR2 Products (1)

mRNA	Protein	Name
NM_003145.4	NP_003136.1	translocon-associated protein subunit beta precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18724357	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSR2 Protein Structure

TRAP_beta

0
100
183 a.a.

Protein Preferred Names	Protein Names
translocon-associated protein subunit beta	SSR-beta

SSR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SSR2	P43308	STING1	Homo sapiens	Q86WV6	Anti Tag CoIP	18724357

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type
Synostoses, Tarsal, Carpal, And Digital	Calcaneonavicular Coalition Multiple Synostosis Syndrome Synostoses, Tarsal, Carpal And Digital
Ectopic Cushing Syndrome	Cushing Syndrome Due To Ectopic Acth Secretion Ectopic Acth Secreting Tumor Adrenocorticotropic Hormone Secretion Syndrome Occult Ectopic Acth Secretion Paraneoplastic Cushing Syndrome
Granulomatous Disease, Chronic, Autosomal Recessive, 3	CGD3 Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3 Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii Granulomatous Disease, Chronic, Due To Ncf4 Deficiency Chronic Granulomatous Disease 3, Autosomal Recessive Autosomal Recessive Chronic Granulomatous Disease 3 Autosomal Recessive Cytochrome B-Positive Cgd Type Iii Cdg3 Chronic Granulomatous Disease Due To Ncf4 Deficiency Cgd Autosomal Recessive Cytochrome B-Positive Type Iii Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii Granulomatous Disease Chronic Due To Ncf4 Deficiency Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3
Tylosis With Esophageal Cancer	Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome TOC Keratosis Palmaris Et Plantaris With Esophageal Cancer Bennion-Patterson Syndrome Howell-Evans Syndrome Keratosis Palmoplantaris-Esophageal Carcinoma Syndrome Palmoplantar Hyperkeratosis-Esophageal Carcinoma Syndrome Tylosis-Oesophageal Carcinoma Syndrome Palmoplantar Keratoderma With Esophageal Cancer Howel-Evans Syndrome Keratosis Palmoplantaris With Esophageal Cancer Tylosis - Oesophageal Carcinoma Howel-Evans' Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13815	SSR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SSR2	VGNC	VGNC:46838
Felis catus	SSR2	VGNC	VGNC:107945
Mus musculus	SSR2	MGD	MGI:1913506
Bos taurus	SSR2	VGNC	VGNC:35320
Macaca mulatta	SSR2	VGNC	VGNC:77889
Rattus norvegicus	SSR2	RGD	RGD:1308365
Others	SSR2	NCBI