Azido-PEG2-C6-Cl
Based on 1 Customer Validation
Azido-PEG2-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C6-Cl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- Reinheit: 95.0%
- CAS. Nr.: 2568146-55-2
- Formel: C10H20ClN3O2
- Molecular Weight:249.74
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Speicherung:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2568146-55-2
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Appearance Liquid
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Molecular Weight 249.74
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Formel C10H20ClN3O2
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Color Colorless to light yellow
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SMILES
ClCCCCCCOCCOCCN=[N+]=[N-]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 250 mg/mL (1001.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
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Data Sheet (266 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0042 mL | 20.0208 mL | 40.0416 mL | 100.1041 mL |
| 5 mM | 0.8008 mL | 4.0042 mL | 8.0083 mL | 20.0208 mL | |
| 10 mM | 0.4004 mL | 2.0021 mL | 4.0042 mL | 10.0104 mL | |
| 15 mM | 0.2669 mL | 1.3347 mL | 2.6694 mL | 6.6736 mL | |
| 20 mM | 0.2002 mL | 1.0010 mL | 2.0021 mL | 5.0052 mL | |
| 25 mM | 0.1602 mL | 0.8008 mL | 1.6017 mL | 4.0042 mL | |
| 30 mM | 0.1335 mL | 0.6674 mL | 1.3347 mL | 3.3368 mL | |
| 40 mM | 0.1001 mL | 0.5005 mL | 1.0010 mL | 2.5026 mL | |
| 50 mM | 0.0801 mL | 0.4004 mL | 0.8008 mL | 2.0021 mL | |
| 60 mM | 0.0667 mL | 0.3337 mL | 0.6674 mL | 1.6684 mL | |
| 80 mM | 0.0501 mL | 0.2503 mL | 0.5005 mL | 1.2513 mL | |
| 100 mM | 0.0400 mL | 0.2002 mL | 0.4004 mL | 1.0010 mL |
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