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Art. -Nr.: HY-W440990

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DOPE-PEG1000-Amine

(Synonyms: DOPE-PEG1000-NH2)

DOPE-PEG1000-Amine (DOPE-PEG1000-NH2) is a conjugate composed of dioleoylphosphatidylethanolamine (DOPE), a PEG chain, and a terminal amino group (-NH2). The amino group in DOPE-PEG1000-Amine can chemically react with carboxyl groups, activated esters, etc., participating in various bioconjugation reactions for targeted modification of liposomes/nanoparticles.

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Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

DOPE-PEG1000-Amine Chemical Structure

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Biologische Aktivität

Beschreibung

In Vitro

The structure of DOPE-PEG-Amine comprises three key parts, which work synergistically:
DOPE: Contains two C18:1 unsaturated fatty acid chains, giving it high fluidity and flexibility in lipid membranes.
PEG chain: Acts as a hydrophilic spacer arm, forming a hydration layer on the particle surface, reducing non-specific adsorption and immune system recognition and clearance, thus prolonging the carrier's circulation time in vivo.
-NH2: A reaction interface located at the end of the PEG chain, capable of chemically reacting with specific groups (such as carboxyl groups, activated esters, etc.) on the surface of drug molecules, proteins, antibodies, or nanoparticles, thereby achieving drug loading.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OCCNC(OCCN)=O)(O)=O)=O.[n]
Synonyms

DOPE-PEG1000-NH2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.