GalNAc-L96 free base
GalNAc-L96 free base is a conjugate of GalNAc and its ligand L96. When conjugated with the A-rich HCV sequence (H12), GalNAc-L96 free base binds potently to ASGPR, with a Ki value of 10.4 nM. GalNAc-L96 free base promotes siRNA delivery to hepatocytes.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1159408-61-3
- Formel: C121H179N11O45
- Molecular Weight:2507.76
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Humanized PCSK9 mice[1]
-
Dosage:6 mg/kg
-
Administration:s.c.; single dose
-
Result:Reduced serum PCSK9 protein levels to ~10.2% of baseline at day 14 post-dose.
Reduced hepatic PCSK9 mRNA levels to ~19.9% of baseline at day 14 post-dose.
Chemical Information
-
CAS. Nr. 1159408-61-3
-
Molecular Weight 2507.76
-
Formel C121H179N11O45
-
SMILES
CC(N[C@H]([C@H]([C@H]([C@H](O1)COC(C)=O)OC(C)=O)OC(C)=O)[C@@H]1OCCCCC(NCCCNC(CCOCC(COCCC(NCCCNC(CCCCO[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)COC(C)=O)OC(C)=O)OC(C)=O)NC(C)=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)COC(C)=O)OC(C)=O)OC(C)=O)NC(C)=O)=O)=O)NC(CCCCCCCCCCC(N(C[C@@H](C4)OC(CCC(O)=O)=O)[C@@H]4COC(C5=CC=C(C=C5)OC)(C6=CC=CC=C6)C7=CC=C(C=C7)OC)=O)=O)=O)=O)=O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Pradeep SP, et al. Enhanced liver-targeted delivery with ribofuranose-based GalNAc conjugates. Mol Ther Nucleic Acids. 2026;37(1):102871. Published 2026 Mar 4. [Content Brief]
[2]. Clua A, et al. Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes. Molecules. 2022;27(12):3944. Published 2022 Jun 20. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Powered by Bioz