PUM2 - pumilio RNA binding family member 2 Gene

Also Known as PUMH2; PUML2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23369

About PUM2

Cytogenetic location: 2p24.1 Genomic coordinates (GRCh38): 2:20,248,691-20,352,253 (from NCBI)

This gene has 10 transcripts (splice variants), 204 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 13.0), lymph node (RPKM 9.6) and 25 other tissues.

Summary

This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

PUM2 Products (15)

mRNA Protein Name
NM_001282752.3 NP_001269681.1 pumilio homolog 2 isoform 2
NM_001282790.2 NP_001269719.1 pumilio homolog 2 isoform 3
NM_001282791.2 NP_001269720.1 pumilio homolog 2 isoform 4
NM_001352917.3 NP_001339846.1 pumilio homolog 2 isoform 5
NM_001352918.2 NP_001339847.1 pumilio homolog 2 isoform 1
NM_001352919.3 NP_001339848.1 pumilio homolog 2 isoform 1
NM_001352920.3 NP_001339849.1 pumilio homolog 2 isoform 6
NM_001352923.3 NP_001339852.1 pumilio homolog 2 isoform 6
NM_001352925.3 NP_001339854.1 pumilio homolog 2 isoform 3
NM_001352926.2 NP_001339855.1 pumilio homolog 2 isoform 3
NM_001352927.3 NP_001339856.1 pumilio homolog 2 isoform 3
NM_001352928.3 NP_001339857.1 pumilio homolog 2 isoform 3
NM_001352929.3 NP_001339858.1 pumilio homolog 2 isoform 4
NM_001352930.3 NP_001339859.1 pumilio homolog 2 isoform 7
NM_015317.5 NP_056132.1 pumilio homolog 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables RNA binding IDA
IDA: Inferred from direct assay
26724866 GOA
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
18776931 GOA
enables miRNA binding IDA
IDA: Inferred from direct assay
28431233 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12511597 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in miRNA processing IMP
IMP: Inferred from mutant phenotype
28431233 GOA
involved in positive regulation of RIG-I signaling pathway IDA
IDA: Inferred from direct assay
25340845 GOA
involved in positive regulation of miRNA-mediated gene silencing IMP
IMP: Inferred from mutant phenotype
22345517 GOA
acts upstream of or within post-transcriptional regulation of gene expression IDA
IDA: Inferred from direct assay
25100735 GOA
acts upstream of positive effect post-transcriptional regulation of gene expression IMP
IMP: Inferred from mutant phenotype
28431233 GOA
involved in regulation of chromosome segregation IDA
IDA: Inferred from direct assay
26724866 GOA
involved in regulation of mRNA stability IDA
IDA: Inferred from direct assay
26724866 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
25340845 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19168546 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PUM2 Protein Structure

PUF

PUF: Pumilio-family RNA binding repeat (727 - 760)

PUF

PUF: Pumilio-family RNA binding repeat (763 - 791)

PUF

PUF: Pumilio-family RNA binding repeat (799 - 830)

PUF

PUF: Pumilio-family RNA binding repeat (835 - 862)

PUF

PUF: Pumilio-family RNA binding repeat (871 - 904)

PUF

PUF: Pumilio-family RNA binding repeat (907 - 939)

PUF

PUF: Pumilio-family RNA binding repeat (942 - 971)

PUF

PUF: Pumilio-family RNA binding repeat (990 - 1019)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1064 a.a.
Protein Preferred Names Protein Names

pumilio homolog 2

  • pumilio-2

PUM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Cross
PUM2 Q8TB72 ORF Human immunodeficiency virus Q9Q2G4
Pull Down
22190034
Intra
PUM2 Q8TB72 DAZ1 Homo sapiens Q9NQZ3
Anti Tag CoIP
12511597
Intra
PUM2 Q8TB72 DAZ1 Homo sapiens Q9NQZ3
Y2H
12511597
Intra
PUM2 Q8TB72 BOLL Homo sapiens Q8N9W6
Affinity Chrom
15806553
Cross: Cross-species interaction Intra: Intraspecies interaction

PUM2 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82841 PUM2 Antibody (YA2586) WB, ICC/IF, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Testis Seminoma

  • Seminoma Of Testis

  • Seminoma Testis

  • Testicular Seminoma Pure

  • Seminoma
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11462 PUM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22291 Pum2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28814 Pum2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PUM2 VGNC VGNC:64437
Rattus norvegicus PUM2 RGD RGD:1311024
Mus musculus PUM2 MGD MGI:1931751
Macaca mulatta PUM2 VGNC VGNC:76480
Bos taurus PUM2 VGNC VGNC:33570
Canis familiaris PUM2 VGNC VGNC:45207
Others PUM2 NCBI