2. Gene
  3. PUM2 - pumilio RNA binding family member 2 Gene

PUM2 - pumilio RNA binding family member 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PUMH2; PUML2

Gene ID: 23369 | Gene type: protein coding

About PUM2

Cytogenetic location: 2p24.1 Genomic coordinates (GRCh38): 2:20,248,691-20,352,253 (from NCBI)

This gene has 10 transcripts (splice variants), 204 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 13.0), lymph node (RPKM 9.6) and 25 other tissues.

Summary

This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

PUM2 Products(15)

mRNA Protein Name
NM_001282752.3 NP_001269681.1 pumilio homolog 2 isoform 2
NM_001282790.2 NP_001269719.1 pumilio homolog 2 isoform 3
NM_001282791.2 NP_001269720.1 pumilio homolog 2 isoform 4
NM_001352917.3 NP_001339846.1 pumilio homolog 2 isoform 5
NM_001352918.2 NP_001339847.1 pumilio homolog 2 isoform 1
NM_001352919.3 NP_001339848.1 pumilio homolog 2 isoform 1
NM_001352920.3 NP_001339849.1 pumilio homolog 2 isoform 6
NM_001352923.3 NP_001339852.1 pumilio homolog 2 isoform 6
NM_001352925.3 NP_001339854.1 pumilio homolog 2 isoform 3
NM_001352926.2 NP_001339855.1 pumilio homolog 2 isoform 3
NM_001352927.3 NP_001339856.1 pumilio homolog 2 isoform 3
NM_001352928.3 NP_001339857.1 pumilio homolog 2 isoform 3
NM_001352929.3 NP_001339858.1 pumilio homolog 2 isoform 4
NM_001352930.3 NP_001339859.1 pumilio homolog 2 isoform 7
NM_015317.5 NP_056132.1 pumilio homolog 2 isoform 1

PUM2 Protein Structure

PUF

PUF: Pumilio-family RNA binding repeat (727 - 760)

PUF

PUF: Pumilio-family RNA binding repeat (763 - 791)

PUF

PUF: Pumilio-family RNA binding repeat (799 - 830)

PUF

PUF: Pumilio-family RNA binding repeat (835 - 862)

PUF

PUF: Pumilio-family RNA binding repeat (871 - 904)

PUF

PUF: Pumilio-family RNA binding repeat (907 - 939)

PUF

PUF: Pumilio-family RNA binding repeat (942 - 971)

PUF

PUF: Pumilio-family RNA binding repeat (990 - 1019)

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  • 1064 a.a.
Protein Preferred Names Protein Names

pumilio homolog 2

pumilio-2

Related Diseases

Diseases Alias
Testis Seminoma

Seminoma Of Testis

Seminoma Testis

Testicular Seminoma Pure

Seminoma
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11462 PUM2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PUM2 VGNC VGNC:64437
Rattus norvegicus PUM2 RGD RGD:1311024
Mus musculus PUM2 MGD MGI:1931751
Macaca mulatta PUM2 VGNC VGNC:76480
Bos taurus PUM2 VGNC VGNC:33570
Canis familiaris PUM2 VGNC VGNC:45207