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Art. -Nr.: HY-155849

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PKM2-IN-4

Pkm2-in-4 (compound 5C) is a selective inhibitor of PKM2 (IC₅₀=0.35 μM), which regulates pyruvate-dependent respiration and induces mitochondrial H202 production rate and electron transport system coupling.

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CAS. Nr.: 2996165-24-1
Formel: C₁₅H₁₇BrClNO₃Se
Molecular Weight:453.62

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PKM2-IN-4 Chemical Structure

CAS. Nr.: 2996165-24-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 0.35 μM (PKM2)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	0.32 μM Compound: 5c	Cytotoxicity against mouse 4T1 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against mouse 4T1 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37216812]
A549	IC₅₀	1.3 μM Compound: 5c	Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37216812]
H9c2	IC₅₀	2.46 μM Compound: 5c	Cytotoxicity against rat H9c2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against rat H9c2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37216812]
HCC1937	IC₅₀	0.33 μM Compound: 5c	Cytotoxicity against human HCC1937 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human HCC1937 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37216812]
Jurkat	IC₅₀	0.44 μM Compound: 5c	Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37216812]
MCF7	IC₅₀	1.16 μM Compound: 5c	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37216812]
MDA-MB-231	IC₅₀	0.51 μM Compound: 5c	Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 37216812]

Chemical Information

CAS. Nr. 2996165-24-1
Molecular Weight 453.62
Formel C₁₅H₁₇BrClNO₃Se
SMILES

BrC1=C([Se][N+]2=C1C=C(C(OC)=O)C=C2)C3(CCCCC3)O.[Cl-]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Dimitrijevs P, et al. Development of isoselenazolium chlorides as selective pyruvate kinase isoform M2 inhibitors. Eur J Med Chem. 2023 Sep 5;257:115504. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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