Desvenlafaxine-d6
Based on 1 Customer Validation
Desvenlafaxine-d6 is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter.
For research use only. We do not sell to patients.
- Purity: 98.89%
- CAS No.: 1062605-69-9
- Formula: C16H19D6NO2
- Molecular Weight:269.41
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1062605-69-9
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Unlabeled Cas 93413-62-8
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Appearance Solid
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Molecular Weight 269.41
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Formula C16H19D6NO2
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SMILES
[2H]C([2H])([2H])N(C([2H])([2H])[2H])CC(C1=CC=C(C=C1)O)C2(CCCCC2)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 50 mg/mL (185.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Deecher, D.C., et al., Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther, 2006. 318(2): p. 657-65. [Content Brief]
[3]. Sopko, M.A., Jr., M.J. Ehret, and M. Grgas, Desvenlafaxine: another "me too" drug? Ann Pharmacother, 2008. 42(10): p. 1439-46. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7118 mL | 18.5591 mL | 37.1181 mL | 92.7954 mL |
| 5 mM | 0.7424 mL | 3.7118 mL | 7.4236 mL | 18.5591 mL | |
| 10 mM | 0.3712 mL | 1.8559 mL | 3.7118 mL | 9.2795 mL | |
| 15 mM | 0.2475 mL | 1.2373 mL | 2.4745 mL | 6.1864 mL | |
| 20 mM | 0.1856 mL | 0.9280 mL | 1.8559 mL | 4.6398 mL | |
| 25 mM | 0.1485 mL | 0.7424 mL | 1.4847 mL | 3.7118 mL | |
| 30 mM | 0.1237 mL | 0.6186 mL | 1.2373 mL | 3.0932 mL | |
| 40 mM | 0.0928 mL | 0.4640 mL | 0.9280 mL | 2.3199 mL | |
| 50 mM | 0.0742 mL | 0.3712 mL | 0.7424 mL | 1.8559 mL | |
| 60 mM | 0.0619 mL | 0.3093 mL | 0.6186 mL | 1.5466 mL | |
| 80 mM | 0.0464 mL | 0.2320 mL | 0.4640 mL | 1.1599 mL | |
| 100 mM | 0.0371 mL | 0.1856 mL | 0.3712 mL | 0.9280 mL |
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