IL27 - interleukin 27 Gene

Also Known as p28; IL30; IL-27; IL27A; IL-27A; IL27p28

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 246778

About IL27

Cytogenetic location: 16p12.1-p11.2 Genomic coordinates (GRCh38): 16:28,499,362-28,506,834 (from NCBI)

This gene has 2 transcripts (splice variants) and 88 orthologues. Biased expression in liver (RPKM 1.5), appendix (RPKM 0.4) and 6 other tissues.

Summary

The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]

IL27 Products (1)

mRNA Protein Name
NM_145659.3 NP_663634.2 interleukin-27 subunit alpha precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19933857 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
12734330 GOA
involved in regulation of T-helper 1 cell differentiation IDA
IDA: Inferred from direct assay
12734330 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-27 subunit alpha

  • IL-27 p28 subunit

IL27 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IL27 Q8NEV9 CRLF1 Homo sapiens O75462
Anti Tag CoIP
19933857
Intra
IL27 Q8NEV9 EBI3 Homo sapiens Q14213
Anti Tag CoIP
20974977
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL27 Proteins

Cat. No. Product Name Accession Purity
HY-P73199 IL-27 Protein, Human (CHO, His) Q14213/NP_005746.2 (R21-K229)&Q8NEV9/NP_663634.2 (F29-P243) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700122AF Animal-Free IL-30/IL-27A Protein, Human (His) Q8NEV9 (F29-P243) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Toxoplasmosis

  • Disseminated Toxoplasmosis

  • Multisystemic Disseminated Toxoplasmosis

  • Acquired Toxoplasmosis

  • Toxoplasmosis Disease Or Disorder

  • Infection By Toxoplasma Gondii

  • Toxoplasmal

  • Toxoplasma
Autoimmune Disease Of Eyes, Ear, Nose And Throat
Autoimmune Uveitis
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990024 Casdozokitug Inhibitor 96.49% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-151508 Diamino lipid DAL4 / Unkown
HY-RS06746 IL27 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06747 IL27RA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08889 MYDGF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174612 Human IL27RA mRNA / Unkown
HY-174613 Human IL27 mRNA / Unkown
HY-RS17022 Ebi3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17036 Il27 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20169 Il27ra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23480 Il27 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26673 Il27ra Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990215 Anti-Mouse IL-27 p28 Antibody (MM27.7B1) Inhibitor 95.00% Unkown
HY-P992246 Anti-IL-27RA Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus IL27 VGNC VGNC:62909
Rattus norvegicus IL27 RGD RGD:1561420
Canis familiaris IL27 VGNC VGNC:41976
Mus musculus IL27 MGD MGI:2384409
Macaca mulatta IL27 VGNC VGNC:99516
Bos taurus IL27 VGNC VGNC:30150
Others IL27 NCBI