CRLF1 - cytokine receptor like factor 1 Gene

Also Known as CLF; NR6; CISS; CISS1; CLF-1; zcytor5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9244

About CRLF1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,593,237-18,606,799 (from NCBI)

This gene has 6 transcripts (splice variants), 173 orthologues, 23 paralogues and is associated with 5 phenotypes. Broad expression in placenta (RPKM 4.8), brain (RPKM 3.2) and 15 other tissues.

Summary

This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]

CRLF1 Products (1)

mRNA Protein Name
NM_004750.5 NP_004741.1 cytokine receptor-like factor 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to ciliary neurotrophic factor receptor binding IDA
IDA: Inferred from direct assay
10966616 GOA
contributes to cytokine activity IDA
IDA: Inferred from direct assay
10966616 GOA
enables cytokine binding IPI
IPI: Inferred from physical interaction
15034937 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10966616 GOA
Biological Process GO Annotation Evidence References Source
involved in cell surface receptor signaling pathway via STAT IDA
IDA: Inferred from direct assay
10966616 GOA
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
10966616 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
10966616 GOA
Cellular Component GO Annotation Evidence References Source
part of CRLF-CLCF1 complex IDA
IDA: Inferred from direct assay
10966616 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRLF1 Protein Structure

EpoR_lig-bind

EpoR_lig-bind: Erythropoietin receptor, ligand binding (133 - 227)

fn3

fn3: Fibronectin type III domain (236 - 312)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 422 a.a.
Protein Preferred Names Protein Names

cytokine receptor-like factor 1

  • class I cytokine receptor

CRLF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CRLF1 O75462 SORL1 Homo sapiens Q92673
SPR
26858303
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Crisponi/Cold-Induced Sweating Syndrome 1

  • Crisponi Syndrome

  • Cold-Induced Sweating Syndrome 1

  • CISS1

  • Sohar-Crisponi Syndrome

  • Muscle Contractions, Tetanoform, With Characteristic Face, Camptodactyly, Hyperthermia, And Sudden Death

  • Muscle Contractions Tetanoform With Characteristic Face Camptodactyly Hyperthermia And Sudden Death
Cold-Induced Sweating Syndrome

  • Crisponi Syndrome

  • Sohar-Crisponi Syndrome

  • Ciss

  • Cntf Receptor-Related Disorders

  • Muscle Contractions, Tetanoform, With Characteristic Face, Camptodactyly, Hyperthermia, And Sudden Death

  • Sweating Syndrome, Cold-Induced
Cold-Induced Sweating Syndrome Including Crisponi Syndrome

  • Crisponi/Cold-Induced Sweating Syndrome
Achalasia

  • Cardiospasm

  • Achalasia Of Cardia

  • Esophageal Achalasia

  • Hypertensive Lower Esophageal Sphincter

  • Idiopathic Achalasia

  • Achalasia Cardia

  • Idiopathic Achalasia Of Esophagus

  • Primary Achalasia

  • Achalasia Of Esophagus

  • Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter

  • Aperistalsis Of The Oesophagus

  • Achalasia Of Oesophagus

  • Oesophageal Achalasia

  • Achalasia Nos

  • Cardia Spasm

  • Cardia Achalasia

  • Oesophageal Cardiospasm

  • Oesophagus Achalasia

  • Reflex Cardiospasm
Crisponi/Cold-Induced Sweating Syndrome 2

  • Cold-Induced Sweating Syndrome 2

  • CISS2

  • Sweating Syndrome, Cold-Induced, Type 2
Retinitis Pigmentosa 42

  • RP42

  • Retinitis Pigmentosa-42

  • Retinitis Pigmentosa, Type 42
Developmental And Epileptic Encephalopathy 11

  • Epileptic Encephalopathy, Early Infantile, 11

  • DEE11

  • Eiee11

  • Developmental And Epileptic Encephalopathy, 11

  • Early Infantile Epileptic Encephalopathy 11

  • Encephalopathy, Developmental And Epileptic, Type 11
Congenital Contractures Of The Limbs And Face, Hypotonia, And Developmental Delay

  • CLIFAHDD

  • Congenital Limbs-Face Contractures-Hypotonia-Developmental Delay Syndrome

  • Clifahdd Syndrome

  • Doid:0081048

  • Contractures, Limbs And Face, Congenital, Hypotonia, And Developmental Delay
Tetanus Neonatorum

  • Neonatal Tetanus

  • NNT

  • Trismus Neonatorum

  • Newborn Trismus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03186 CRLF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20387 Crlf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26897 Crlf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CRLF1 VGNC VGNC:109610
Canis familiaris CRLF1 VGNC VGNC:39620
Felis catus CRLF1 VGNC VGNC:61183
Rattus norvegicus CRLF1 RGD RGD:1311371
Bos taurus CRLF1 VGNC VGNC:27717
Mus musculus CRLF1 MGD MGI:1340030
Others CRLF1 NCBI