NRN1 - neuritin 1 Gene

Also Known as NRN; dJ380B8.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51299

About NRN1

Cytogenetic location: 6p25.1 Genomic coordinates (GRCh38): 6:5,997,999-6,007,518 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 1 paralogue. Broad expression in brain (RPKM 29.3), fat (RPKM 22.7) and 14 other tissues.

Summary

This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

NRN1 Products (3)

mRNA Protein Name
NM_001278710.2 NP_001265639.1 neuritin isoform 1 precursor
NM_001278711.2 NP_001265640.1 neuritin isoform 2
NM_016588.3 NP_057672.1 neuritin isoform 1 precursor

NRN1 Protein Structure

NRN1

NRN1: Neuritin protein family (31 - 118)

  • 0
  • 100
  • 142 a.a.
Protein Preferred Names Protein Names

neuritin

Recombinant NRN1 Proteins

Cat. No. Product Name Accession Purity
HY-P71908A Neuritin Protein, Human (N-His) Q9NPD7 (A28-N115) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Severe Congenital Neutropenia 8

  • Autosomal Dominant Severe Congenital Neutropenia 8 With Or Without Pancreatic Dysfunction And/Or Neurological Abnormalities

  • Scn8

  • Sdsl

  • Shwachman-Diamond Syndrome-Like
Spinal Muscular Atrophy, Type I

  • Werdnig-Hoffmann Disease

  • SMA1

  • Spinal Muscular Atrophy 1

  • Sma I

  • Sma, Infantile Acute Form

  • Muscular Atrophy, Infantile

  • Spinal Muscular Atrophy-1

  • Hmn Proximal Type I

  • Infantile Muscular Atrophy

  • Proximal Spinal Muscular Atrophy Type 1

  • Sma Type 1

  • Sma Type I

  • Sma-I

  • Hereditary Motor Neuropathy Proximal Type I

  • Progressive Muscular Atrophy Of Infancy

  • Proximal Spinal Muscular Atrophy, Type 1

  • Werdnig Hoffmann Disease

  • Infantile Spinal Muscular Atrophy

  • Infantile-Onset Spinal Muscular Atrophy

  • Proximal Hereditary Motor Neuropathy Type I

  • Sma Infantile Acute Form

  • Spinal Muscular Atrophy Type I

  • Werdnig-Hoffman Disease

  • Atrophy, Muscular, Spinal, Type 1
Spinal Muscular Atrophy, Type Iii

  • SMA3

  • Juvenile Spinal Muscular Atrophy

  • Kugelberg-Welander Disease

  • Sma Iii

  • Kugelberg-Welander Syndrome

  • Kws

  • Muscular Atrophy, Juvenile

  • Spinal Muscular Atrophy, Mild Childhood And Adolescent Form

  • Spinal Muscular Atrophy-3

  • Spinal Muscular Atrophy Type 3

  • Spinal Muscular Atrophy, Type Iii, Modifier Of

  • Type Iii Spinal Muscular Atrophy

  • Sma 3

  • Proximal Spinal Muscular Atrophy Type 3

  • Sma Type 3

  • Sma Type Iii

  • Sma-Iii

  • Spinal Muscular Atrophy 3

  • Spinal Muscular Atrophy Mild Childhood And Adolescent Form

  • Spinal Muscular Atrophy Type Iii

  • Wohlfart-Kugelberg-Welander Disease

  • Atrophy, Muscular, Spinal, Type Iii
Autosomal Dominant Severe Congenital Neutropenia

  • Severe Congenital Neutropenia Autosomal Dominant

  • Neutropenia, Congenital, Severe, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09577 NRN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09578 NRN1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18253 Nrn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20070 Nrn1l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24733 Nrn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26574 Nrn1l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NRN1 VGNC VGNC:32265
Canis familiaris NRN1 VGNC VGNC:43973
Felis catus NRN1 VGNC VGNC:63881
Rattus norvegicus NRN1 RGD RGD:621586
Macaca mulatta NRN1 VGNC VGNC:104417
Mus musculus NRN1 MGD MGI:1915654
Others NRN1 NCBI