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UIMC1 - ubiquitin interaction motif containing 1 Gene

Also Known as RAP80; X2HRIP110

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51720

About UIMC1

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:176,905,005-177,022,602 (from NCBI)

This gene has 14 transcripts (splice variants) and 189 orthologues. Broad expression in testis (RPKM 26.7), bone marrow (RPKM 12.5) and 24 other tissues.

Summary

This gene encodes a nuclear protein that interacts with Brca1 (breast Cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

UIMC1 Products (4)

mRNA	Protein	Name
NM_001199297.2	NP_001186226.1	BRCA1-A complex subunit RAP80 isoform 1
NM_001199298.2	NP_001186227.1	BRCA1-A complex subunit RAP80 isoform 1
NM_001317961.1	NP_001304890.1	BRCA1-A complex subunit RAP80 isoform 2
NM_016290.4	NP_057374.3	BRCA1-A complex subunit RAP80 isoform 1

Protein Preferred Names	Protein Names
BRCA1-A complex subunit RAP80	receptor-associated protein 80

UIMC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UIMC1	Q96RL1	ABRAXAS1	Homo sapiens	Q6UWZ7	Anti Bait CoIP	17525340
Intra	UIMC1	Q96RL1	ABRAXAS1	Homo sapiens	Q6UWZ7	Anti Tag CoIP	19615732
Intra	UIMC1	Q96RL1	BRCA1	Homo sapiens	P38398	Anti Bait CoIP	17525340
Intra	UIMC1	Q96RL1	BRCA1	Homo sapiens	P38398	Pull Down	17525340
Intra	UIMC1	Q96RL1	BLM	Homo sapiens	P54132	Anti Bait CoIP	23708797
Intra	UIMC1	Q96RL1	DVL2	Homo sapiens	O14641	Y2H Array	31515488

Cross: Cross-species interaction Intra: Intraspecies interaction

UIMC1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83463	RAP80 Antibody (YA3208)	WB, IHC-F, IHC-P, ICC/IF	Human
HY-P83463A	RAP80 Antibody (YA3208)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human

Related Diseases

Diseases	Alias
Arthrogryposis, Renal Dysfunction, And Cholestasis 1	Arc Syndrome ARCS1 Arthrogryposis Renal Dysfunction Cholestasis Syndrome Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome Arcs Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome Arthrogryposis, Renal Dysfunction, And Cholestasis Arthrogryposis-Renal Dysfunction-Cholestasis Arthrogryposis - Renal Dysfunction - Cholestasis Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1 Arthrogryposis Renal Dysfunction And Cholestasis 1 Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1 Kidney Failure Renal Insufficiency
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15447	UIMC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UIMC1	RGD	RGD:1307009
Mus musculus	UIMC1	MGD	MGI:103185
Bos taurus	UIMC1	VGNC	VGNC:36657
Canis familiaris	UIMC1	VGNC	VGNC:48127
Macaca mulatta	UIMC1	VGNC	VGNC:79842
Felis catus	UIMC1	VGNC	VGNC:66813
Others	UIMC1	NCBI