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Cat. No.: HY-E70398

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Sorbitol dehydrogenase

(Synonyms: L-Iditol dehydrogenase; Polyol dehydrogenase; SDH)

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Sorbitol dehydrogenase (L-Iditol dehydrogenase) is an oxidoreductasea and catalyses the conversion of sorbitol to fructose with NAD⁺ as the coenzyme. Sorbitol dehydrogenase catalyses pH-dependent redox reactions between NAD⁺/NADH and sorbitol/fructose. Sorbitol dehydrogenase is implicated in diabetic complications and is a biomarker of drug-induced liver injury. Sorbitol dehydrogenase can be used for the research of diabetes and liver injury.

For research use only. We do not sell to patients.

CAS No.: 9028-21-1

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Sorbitol dehydrogenase Chemical Structure

CAS No.: 9028-21-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

In Vitro

Sorbitol dehydrogenase exhibits substrate inhibition at sorbitol concentrations >30 mM and fructose concentrations >100 mM at pH 7.4, with dissociation of the enzyme-coenzyme binary complex as the rate-limiting reaction step^[1].
Sorbitol dehydrogenase exhibits higher apparent affinity for fructose and NADH than for sorbitol and NAD⁺^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 9028-21-1
Appearance Solid
Color White to off-white
SMILES

[Sorbitol dehydrogenase]
Synonyms

L-Iditol dehydrogenase; Polyol dehydrogenase; SDH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. El-Kabbani O, et al. Sorbitol dehydrogenase: structure, function and ligand design. Curr Med Chem. 2004 Feb;11(4):465-76. [Content Brief]

[2]. Bekhit M, et al. Determination of sorbitol dehydrogenase in microsamples of human serum. Talanta. 2021;235:122730. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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