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Cat. No.: HY-129286

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ASN 05397535

ASN 05397535 is an anticancer agent. ASN 05397535 can be used in the research of colon adenocarcinoma and prostate cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 601502-36-7
Formule: C₂₁H₁₆ClN₃O₃
Masse moléculaire:393.83

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ASN 05397535 Chemical Structure

CAS No.: 601502-36-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

ASN 05397535 is an anticancer agent. ASN 05397535 can be used in the research of colon adenocarcinoma and prostate cancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	GI₅₀	<1 μM Compound: 49	Cytotoxicity in HEK293 cells assessed as growth inhibition measured after 48 hrs by MTT assay Cytotoxicity in HEK293 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 27153347]
LNCaP	GI₅₀	<1 μM Compound: 49	Cytotoxicity in human LNCAP cells assessed as growth inhibition measured after 48 hrs by MTT assay Cytotoxicity in human LNCAP cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 27153347]
MDA-MB-231	GI₅₀	<1 μM Compound: 49	Cytotoxicity in human MDA-MB-231 cells assessed as growth inhibition measured after 48 hrs by MTT assay Cytotoxicity in human MDA-MB-231 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 27153347]
U-937	GI₅₀	<1 μM Compound: 49	Cytotoxicity in human U937 cells assessed as growth inhibition measured after 48 hrs by MTT assay Cytotoxicity in human U937 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 27153347]

In Vitro

ASN 05397535 exhibits almost no direct inhibitory activity against the ATP-binding sites of Aurora-A and Aurora-B^[1].
ASN 05397535 (10 μM) exhibits inhibitory activity against DU145 and HT-29, with GI₅₀ values of 32.95 μM and 1.03 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 601502-36-7
Masse moléculaire 393.83
Formule C₂₁H₁₆ClN₃O₃
SMILES

ClC=1C=CC2=NC(C=3C=CC=CC3O)=C(NCC4=CC=C5OCOC5=C4)N2C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Morshed MN. Identification of Aurora-A Inhibitors by Ligand and Structure-Based Virtual Screening. Mol Inform. 2014 May;33(5):369-81.
[Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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