1929-30-2
Chemical Structure
4-Methoxycinnamic acid ethyl ester
Synonym(s): Ethyl p-methoxycinnamate
- CAS No.: 1929-30-2
- Formula:C12H14O3
- Molecular Weight:206.24
IUPAC Name: ethyl (E)-3-(4-methoxyphenyl)acrylate
InChIKey: DHNGCHLFKUPGPX-RMKNXTFCSA-N
SMILES: O=C(OCC)/C=C/C1=CC=C(OC)C=C1
Biological Activity: 4-Methoxycinnamic acid ethyl ester (Ethyl p-methoxycinnamate) is an orally active natural compound found. 4-Methoxycinnamic acid ethyl ester exerts anti-inflammatory effects by inhibiting cyclooxygenase (COX-1 (IC50 = 1.12 μM) and COX-2 (IC50 = 0.83 μM)), NF-κB (IC50 = 88.7 μM) and cytokine production (TNF-α (IC50 = 96.84 μg/mL) and IL-1β (IC50 = 166.4 μg/mL)). 4-Methoxycinnamic acid ethyl ester inhibits tumor cell proliferation, migration and cancer metabolism and induces apoptosis.4-Methoxycinnamic acid ethyl ester inhibits VEGF expression, thereby inhibiting angiogenesis. 4-Methoxycinnamic acid ethyl ester has a significant inhibitory effect on dengue virus and Mycobacterium tuberculosis. 4-Methoxycinnamic acid ethyl ester has analgesic effects in rats[1][2][3][4][5][6][7].
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4-Methoxycinnamic acid ethyl ester | 98.72% | 4-Methoxycinnamic acid ethyl ester (Ethyl p-methoxycinnamate) is an orally active natural compound found. 4-Methoxycinnamic acid ethyl ester exerts anti-inflammatory effects by inhibiting cyclooxygenase (COX-1 (IC50 = 1.12 μM) and COX-2 (IC50 = 0.83 μM)), NF-κB (IC50 = 88.7 μM) and cytokine production (TNF-α (IC50 = 96.84 μg/mL) and IL-1β (IC50 = 166.4 μg/mL)). 4-Methoxycinnamic acid ethyl ester inhibits tumor cell proliferation, migration and cancer metabolism and induces apoptosis.4-Methoxycinnamic acid ethyl ester inhibits VEGF expression, thereby inhibiting angiogenesis. 4-Methoxycinnamic acid ethyl ester has a significant inhibitory effect on dengue virus and Mycobacterium tuberculosis. 4-Methoxycinnamic acid ethyl ester has analgesic effects in rats. | ||||||||||||||||||||
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- [1]. Umar MI, et al. Bioactivity-Guided Isolation of Ethyl-p-methoxycinnamate, an Anti-inflammatory Constituent, from Kaempferia galanga L. Extracts. Molecules. 2012 Jul 23;17(7):8720-34. [Content Brief]
- [2]. Umar MI, et al. Ethyl-p-methoxycinnamate isolated from Kaempferia galanga inhibits inflammation by suppressing interleukin-1, tumor necrosis factor-α, and angiogenesis by blocking endothelial functions. Clinics (Sao Paulo). 2014 Feb;69(2):134-44. [Content Brief]
- [3]. Lakshmanan D, et al. Ethyl p-methoxycinnamate isolated from a traditional anti-tuberculosis medicinal herb inhibits drug resistant strains of Mycobacterium tuberculosis in vitro. Fitoterapia. 2011 Jun;82(4):757-61. [Content Brief]
- [4]. Lallo S, et al. Ethyl P-Methoxycinnamate: An Active Anti-Metastasis Agent and Chemosensitizer Targeting NFKB from Kaempferia galanga for Melanoma Cells. Life (Basel). 2022 Mar 24;12(4):337. [Content Brief]
- [5]. Tarasuk M, et al. Dual action effects of ethyl-p-methoxycinnamate against dengue virus infection and inflammation via NF-kB pathway suppression. Sci Rep. 2024 Apr 23;14(1):9322. [Content Brief]
- [6]. Sasaki Y, et al. Ethyl p-methoxycinnamate inhibits tumor growth by suppressing fatty acid synthesis and depleting ATP. Sci Rep. 2025 May 2;15(1):15317. [Content Brief]
- [7]. Umar MI, et al. Cytotoxic and Pro-Apoptotic Properties of Ethyl-p-Methoxycinnamate and Its Hydrophilic Derivative Potassium-p-Methoxycinnamate. Chemistry Africa. 2018 Jul 31;1(1-2):87-95.
Keywords
