FTO-IN-15
FTO-IN-15 (Compound 8a) is a potent and selective dual-competitive FTO inhibitor with an IC50 of 43.7 nM, showing high selectivity over ALKBH3 and ALKBH5. FTO-IN-15 substantially inhibits FTO demethylation by simultaneously occupying the substrate and 2-oxoglutarate (2-OG) pockets. FTO-IN-15 can be used for the research of acute myeloid leukemia (AML).
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- Formule: C20H17Cl2N3O6
- Masse moléculaire:466.27
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 1.3 μM[1]
FTO-IN-15 (compound 8a) (0-50 μM) functions as a competitive inhibitor for the 2-OG binding pocket of FTO, as evidenced by the dose-dependent reversal of its inhibitory activity by increasing concentrations of 2-OG in a cell-free enzymatic assay[1].
FTO-IN-15 exhibits potent FTO inhibitory activity, with an IC50 of 43.7 nM in a cell-free dot blot assay and 1.3 μM in a PAGE-based demethylation assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 466.27
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Formule C20H17Cl2N3O6
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SMILES
O=C(/C=C/C(NCCNC(C1=CC(Cl)=C(C(Cl)=C1)NC2=CC=CC=C2C(O)=O)=O)=O)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FTO-IN-15 Related Classifications
HY-179266 Related Classifications
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