RPS6KA3 - ribosomal protein S6 kinase A3 Gene

Also Known as CLS; RSK; HU-3; RSK2; MRX19; ISPK-1; XLID19; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6197

About RPS6KA3

Cytogenetic location: Xp22.12 Genomic coordinates (GRCh38): X:20,149,911-20,267,097 (from NCBI)

This gene has 16 transcripts (splice variants), 252 orthologues, 7 paralogues and is associated with 8 phenotypes. Ubiquitous expression in appendix (RPKM 16.2), colon (RPKM 16.0) and 25 other tissues.

Summary

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]

RPS6KA3 Products (17)

mRNA	Protein	Name
XM_011545555.2	XP_011543857.1	ribosomal protein S6 kinase alpha-3 isoform X1
XM_017029718.3	XP_016885207.1	ribosomal protein S6 kinase alpha-3 isoform X10
XM_005274577.4	XP_005274634.1	ribosomal protein S6 kinase alpha-3 isoform X12
XM_047442334.1	XP_047298290.1	ribosomal protein S6 kinase alpha-3 isoform X8
XM_017029717.3	XP_016885206.1	ribosomal protein S6 kinase alpha-3 isoform X8
NM_004586.3	NP_004577.1	ribosomal protein S6 kinase alpha-3
XM_011545561.3	XP_011543863.1	ribosomal protein S6 kinase alpha-3 isoform X6
XM_017029719.3	XP_016885208.1	ribosomal protein S6 kinase alpha-3 isoform X11
XM_047442332.1	XP_047298288.1	ribosomal protein S6 kinase alpha-3 isoform X3
XM_011545557.3	XP_011543859.1	ribosomal protein S6 kinase alpha-3 isoform X6
XM_011545560.2	XP_011543862.1	ribosomal protein S6 kinase alpha-3 isoform X6
XM_005274573.3	XP_005274630.1	ribosomal protein S6 kinase alpha-3 isoform X4
XM_047442336.1	XP_047298292.1	ribosomal protein S6 kinase alpha-3 isoform X11
XM_011545562.3	XP_011543864.1	ribosomal protein S6 kinase alpha-3 isoform X7
XM_011545556.2	XP_011543858.1	ribosomal protein S6 kinase alpha-3 isoform X2
XM_047442333.1	XP_047298289.1	ribosomal protein S6 kinase alpha-3 isoform X5
XM_047442335.1	XP_047298291.1	ribosomal protein S6 kinase alpha-3 isoform X9

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Références	Source
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IDA IDA: Inferred from direct assay	18402937	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10094392	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	18402937	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22065586	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS6KA3 Protein Structure

Pkinase

Pkinase_C

Pkinase

0
200
400
600
740 a.a.

Protein Preferred Names	Protein Names
ribosomal protein S6 kinase alpha-3	MAP kinase-activated protein kinase 1b MAPK-activated protein kinase 1b MAPKAP kinase 1b MAPKAPK-1b RSK-2 S6K-alpha-3 epididymis secretory sperm binding protein insulin-stimulated protein kinase 1 p90-RSK 3 ribosomal S6 kinase 2 ribosomal protein S6 kinase, 90kDa, polypeptide 3

RPS6KA3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	RPS6KA3	P51812	CSNK2B	Homo sapiens	P67870	Pull Down	32707033
Intra	RPS6KA3	P51812	CSNK2B	Homo sapiens	P67870	Anti Tag CoIP	35271311
Intra	RPS6KA3	P51812	CSNK2B	Homo sapiens	P67870	Anti Tag CoIP	31980649
Intra	RPS6KA3	P51812	CSNK2B	Homo sapiens	P67870	Y2H	10094392
Intra	RPS6KA3	P51812	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	RPS6KA3	P51812	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	RPS6KA3	P51812	MAPK1	Homo sapiens	P28482	Pull Down	32707033
Intra	RPS6KA3	P51812	MAPK1	Homo sapiens	P28482	PLA	25241761
Intra	RPS6KA3	P51812	MAPK1	Homo sapiens	P28482	Y2H	21988832
Cross	RPS6KA3	P51812	yopM	Yersinia enterocolitica serotype O:8/biotype 1B	A1JU68	Anti Bait CoIP	25513777

Cross: Cross-species interaction Intra: Intraspecies interaction

RPS6KA3 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P80850	Phospho-RSK2 (Ser227) Antibody (YA156)	WB, IP	Human, Mouse, Rat
HY-P85356	RSK2 Antibody (YA5048)	WB; IHC-P; IHC-F; FC; IF-Tissue	Human, Mouse, Rat
HY-P86159	RSK2 Antibody (YA5851)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, X-Linked 19	XLID19 Mrx19 Mrx31
Chromosome 16p13.3 Deletion Syndrome, Proximal	Rubinstein-Taybi Syndrome Broad Thumb-Hallux Syndrome Chromosome 16p13.3 Deletion Syndrome Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion Rubinstein Syndrome Broad Thumbs-Halluces Syndrome Rsts Rubinstein-Taybi Deletion Syndrome Rsts Deletion Syndrome Proximal Chromosome 16p13.3 Deletion Syndrome 16p13.3 Deletion Syndrome Broad Thumbs And Great Toes, Characteristic Facies, And Mental Retardation Rts
Hypertelorism	Eyes Wide Apart Eyes Widely Set Hypertelorism Of Orbit Ocular Hypertelorism Orbital Separation Excessive
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Ventricular Septal Defect	Ventricular Septal Defects Interventricular Septal Defect Heart Septal Defects, Ventricular Ventricular Septal Abnormality Interventricular Septum Defect Ventricular Septum Defect Vsd - [Ventricular Septum Defect] Congenital Ventricular Septal Defect Single Ventricular Septal Defect
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability
Symptomatic Form Of Coffin-Lowry Syndrome In Female Carriers
Non-Syndromic X-Linked Intellectual Disability 73	Mrx73 X-Linked Mental Retardation 73
Coffin-Lowry Syndrome	CLS Mental Retardation With Osteocartilaginous Abnormalities Coffin Syndrome 1 Coffin Syndrome Dwarfism, Lean Spastic Type Lean Spastic Dwarfism Coffin Lowry Syndrome
Non-Syndromic X-Linked Intellectual Disability 19	Mrx19
Orthostatic Intolerance	Mitral Valve Prolapse Neurocirculatory Asthenia Mitral Valve Prolapse Syndrome Irritable Heart Systolic Click-Murmur Syndrome Soldiers Heart Cardiovascular Malfunction Arising From Mental Factors Cardiovascular Neurosis Da Costa'S Syndrome Krishaber'S Disease Barlow'S Syndrome Floppy Mitral Valve Mitral Leaflet Syndrome Myxomatous Mitral Valve Prolapse Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency Orthostatic Intolerance Due To Net Deficiency Pots Due To Net Deficiency OI Intolerance, Orthostatic Mitral Valve Prolapse, Familial, X-Linked Ballooning Mitral Valve Barlow Syndrome Flail Mitral Leaflet Myxomatous Mitral Valve Mitral Valve Prolapse-Click Syndrome Prolapsing Mitral Valve Leaflet Syndrome Billowing Mitral Valve Leaflet Posterior Mitral Leaflet Deformity Ballooning Posterior Leaflet Syndrome Blue Valve Syndrome Floppy Mitral Valve Syndrome Mitral Valvular Prolapse Systolic Click Syndrome
Hypotonia
Specific Learning Disability	Specific Learning Difficulty Specific Learning Disorder
Hemochromatosis, Type 1	Hemochromatosis Hemochromatosis Type 1 Hereditary Hemochromatosis Hh HFE1 Hfe Hemochromatosis, Modifier Of Symptomatic Form Of Classic Hemochromatosis Symptomatic Form Of Hemochromatosis Type 1 Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis Haemochromatosis Iron Storage Disorder Bronze Diabetes Hlah Hfe Hemochromatosis, Hereditary Diabetes Bronze Classic Hemochromatosis Hfe-Associated Hereditary Hemochromatosis Hemochromatosis Classic Bronzed Cirrhosis Familial Hemochromatosis Genetic Hemochromatosis Hc Hereditary Haemochromatosis Pigmentary Cirrhosis Primary Hemochromatosis Troisier-Hanot-Chauffard Syndrome Von Recklenhausen-Applebaum Disease Hemochromatosis 1 Primary Hereditary Hemochromatosis Bronze Cirrhosis
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-148061	DB1113		99.86%	Unkown
HY-148063	DB0614		99.92%	Unkown
HY-150643	RSK2-IN-2	Inhibitor	/	Unkown
HY-150717	RSK2-IN-3	Inhibitor	/	Unkown
HY-RS12254	RPS6KA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12255	Rps6ka3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12256	Rps6ka3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RPS6KA3	RGD	RGD:1563860
Mus musculus	RPS6KA3	MGD	MGI:104557
Canis familiaris	RPS6KA3	VGNC	VGNC:45740
Bos taurus	RPS6KA3	VGNC	VGNC:34142
Macaca mulatta	RPS6KA3	VGNC	VGNC:76929
Felis catus	RPS6KA3	VGNC	VGNC:64756
Others	RPS6KA3	NCBI