TRIM56 - tripartite motif containing 56 Gene

Also Known as RNF109

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81844

About TRIM56

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:101,085,481-101,097,967 (from NCBI)

This gene has 4 transcripts (splice variants), 119 orthologues and 80 paralogues. Ubiquitous expression in spleen (RPKM 9.3), ovary (RPKM 7.5) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in several processes, including defense response to Other organism; positive regulation of macromolecule metabolic process; and protein K63-linked ubiquitination. Predicted to be located in cytoplasm. Predicted to be active in chromatin and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TRIM56 Products (1)

mRNA Protein Name
NM_030961.3 NP_112223.1 E3 ubiquitin-protein ligase TRIM56

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
22948160 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
29426904 GOA
Biological Process GO Annotation Evidence Références Source
involved in defense response to virus IDA
IDA: Inferred from direct assay
29426904 GOA
involved in positive regulation of innate immune response IDA
IDA: Inferred from direct assay
29426904 GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
35952808 GOA
involved in positive regulation of type I interferon-mediated signaling pathway IDA
IDA: Inferred from direct assay
29426904 GOA
involved in protein monoubiquitination IDA
IDA: Inferred from direct assay
29426904 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM56 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (21 - 59)

zf-B_box

zf-B_box: B-box zinc finger (165 - 205)

  • 0
  • 200
  • 400
  • 600
  • 755 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM56

  • RING finger protein 109

TRIM56 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P81639 TRIM56 Antibody (YA1384) WB, ICC/IF Human
HY-P81639A TRIM56 Antibody (YA1384)(PBS only) WB, ICC/IF Human

Related Diseases

Diseases Alias
Postinfectious Encephalitis

  • Postinfective Encephalitis

  • Secondary Encephalitis
Aicardi-Goutieres Syndrome

  • Aicardi Goutieres Syndrome

  • Cree Encephalitis

  • Aicardi-Goutières Syndrome

  • Encephalopathy With Basal Ganglia Calcification

  • Ags

  • Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

  • Pseudotoxoplasmosis Syndrome

  • Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

  • Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

  • Aicardi-Goutieres Syndrome 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-185123 Pig TRIM56 mRNA / Unkown
HY-RS15057 TRIM56 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21963 Trim56 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28480 Trim56 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TRIM56 VGNC VGNC:36342
Felis catus TRIM56 VGNC VGNC:103755
Macaca mulatta TRIM56 VGNC VGNC:79173
Mus musculus TRIM56 MGD MGI:2685298
Rattus norvegicus TRIM56 RGD RGD:40958426
Others TRIM56 NCBI