CASP8AP2 - caspase 8 associated protein 2 Gene

Also Known as CED-4; FLASH; RIP25

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9994

About CASP8AP2

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:89,829,880-89,874,436 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele and 203 orthologues. Ubiquitous expression in lymph node (RPKM 5.6), testis (RPKM 4.6) and 25 other tissues.

Summary

This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of Caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and Caspase 8, and plays a regulatory role in Fas-mediated Apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008]

CASP8AP2 Products (3)

mRNA	Protein	Name
NM_001137667.2	NP_001131139.1	CASP8-associated protein 2
NM_001137668.2	NP_001131140.1	CASP8-associated protein 2
NM_012115.4	NP_036247.1	CASP8-associated protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables SUMO polymer binding	IDA IDA: Inferred from direct assay	23086935	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12477726	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	12477726	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in Fas signaling pathway	IMP IMP: Inferred from mutant phenotype	17245429	GOA
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	17245429	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	17245429	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in PML body	IDA IDA: Inferred from direct assay	17245429	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12477726	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	17245429	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12477726	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
CASP8-associated protein 2	FLASH homolog RIP25

CASP8AP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	CASP8AP2	Q9UKL3	PIAS1	Homo sapiens	O75925	Pull Down	21338522
Intra	CASP8AP2	Q9UKL3	PIAS1	Homo sapiens	O75925	Y2H	21338522
Intra	CASP8AP2	Q9UKL3	SP100	Homo sapiens	P23497	Anti Bait CoIP	17245429
Intra	CASP8AP2	Q9UKL3	SP100	Homo sapiens	P23497	Y2H	17245429
Intra	CASP8AP2	Q9UKL3	CASP8	Homo sapiens	Q14790	Anti Tag CoIP	17245429
Intra	CASP8AP2	Q9UKL3	CASP8	Homo sapiens	Q14790	Anti Bait CoIP	17245429

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Alpha Thalassemia-Intellectual Disability Syndrome Type 1	Alpha Thalassemia-Intellectual Disability Syndrome, Deletion Type Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16 Atr Syndrome Linked To Chromosome 16 Atr Syndrome, Deletion Type Atr-16 Syndrome Alpha Thalassemia-Retardation Syndrome Alpha-Thalassemia/Mental Retardation Syndrome, Deletion-Type Alpha-Thalassemia/Mental Retardation Syndrome, Type 1 Alpha-Thalassemia Mental Retardation Syndrome, Deletion-Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS01968	CASP8AP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CASP8AP2	VGNC	VGNC:26785
Rattus norvegicus	CASP8AP2	RGD	RGD:1305771
Felis catus	CASP8AP2	VGNC	VGNC:60385
Macaca mulatta	CASP8AP2	VGNC	VGNC:70548
Canis familiaris	CASP8AP2	VGNC	VGNC:38737
Mus musculus	CASP8AP2	MGD	MGI:1349399
Others	CASP8AP2	NCBI