Imaprelimab (powder)
Imaprelimab (powder) is a humanized IgG1κ anti-CD146 antibody. Imaprelimab (powder) exerts anti-angiogenic effects on brain metastasis of lung cancer in animal models. Imaprelimab (powder) can be used in studies related to brain metastasis of non-small cell lung cancer.
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Human IgG1 kappa
Human
Imaprelimab (10 mg/kg; i.p.; every two days; 3 weeks) inhibits intracranial non-small cell lung carcinoma brain metastasis growth and angiogenesis more potently than Bevacizumab (HY-P9906) in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB-c-nu (female, 4-6 weeks old)[1]
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Dosage:10 mg/kg
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Administration:i.p.; every two days; 21 days
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Result:Significantly suppressed subcutaneous tumor growth compared with vehicle control and bevacizumab.
Reduced final tumor weight and lower tumor vascular density (measured via MRI F-value).
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Animal Model:BALB-c-nu (female, 4-6 weeks old)[1]
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Dosage:10 mg/kg
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Administration:i.p.; every two days; 3 weeks
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Result:Significantly suppressed intracranial tumor growth (measured via bioluminescence photo flux) compared with vehicle control and bevacizumab.
Reduced intracranial tumor vascular density (measured by CD31-positive vessel count per field) more effectively than bevacizumab.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG1-kappa
ELISA, FACS, Functional assay
Chemical Information
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SMILES
[Imaprelimab (powder)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Imaprelimab (powder) Related Classifications
Cat. No.: HY-P99658A
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- Imaprelimab (powder)
- Transmembrane Glycoprotein
- non-small cell lung carcinoma-derived brain metastasis
- anti-angiogenic agent
- CD146
- animal models
- lung cancer brain metastasis
- intracranial non-small cell lung carcinoma brain metastasis
- bevacizumab
- subcutaneous non-small cell lung carcinoma brain metastasis mouse model
- Inhibitor
- inhibitor
- inhibit