Indatraline hydrochloride
Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine). Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces autophagy while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis.
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- CAS No.: 96850-13-4
- Formule: C16H16Cl3N
- Masse moléculaire:328.66
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
monoamine transporter[1]
Indatraline (0~5 μM; 24 hours; EGFP-LC3 stable cells) hydrochloride makes the concentration-dependent conversion of LC3[1].
Indatraline (1~10 μM; 24 hours; HeLa cells) hydrochloride makes EGFP-LC3 fluorescent vacuoles increased concentration-dependently in the cytoplasm[1].
Indatraline (1~20 μM; smooth muscle cells) hydrochloride inhibits smooth muscle cells proliferation with an IC50 of 15 μM. Indatraline hydrochloride induces autophagy in cells. Indatraline hydrochloride affects AMPK/mTOR/S6K signaling axis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells
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Concentration:0~5 μM
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Incubation Time:24 hours
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Result:Made the concentration-dependent conversion of LC3.
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Cell Line:EGFP-LC3 stable cells
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Concentration:1~10 μM
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Incubation Time:24 hours
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Result:EGFP-LC3 fluorescent vacuoles increased concentration-dependently in the cytoplasm.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 96850-13-4
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Appearance Solid
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Masse moléculaire 328.66
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Formule C16H16Cl3N
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Color White to off-white
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SMILES
CN[C@@H]1C[C@@H](C2=CC=C(Cl)C(Cl)=C2)C3=C1C=CC=C3.[H]Cl
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Synonyms
Lu 19-005
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Portuguese - PT (458 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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