JVW-1009
JVW-1009 is a Sig2R/PGRMC1 antagonist (Sig1R Ki = 96 nM; Sig2R Ki = 70 nM). JVW-1009 acts as a neuroprotective agent. JVW-1009 can be used in the research of Alzheimer's disease.
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- CAS No.: 2089059-30-1
- Formule: C24H24N2
- Masse moléculaire:340.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Sigma 1 Receptor 96 nM (Ki) |
Sigma 2 Receptor 70 nM (Ki) |
JVW-1009 binds to purified Sig1R (Ki = 96 nM) and Sig2R (Ki = 70 nM) with approximately equivalent affinity[1].
JVW-1009 (200 μM; 5-day) significantly reduces age-dependent neurodegeneration of VC4 and VC5 cholinergic neurons in SC_APP *Caenorhabditis elegans* via a PGRMC1-mediated pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2089059-30-1
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Masse moléculaire 340.47
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Formule C24H24N2
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SMILES
C(N1[C@]2(C=3C([C@@](C2)(CC1)[H])=CC=C(NC4=CC=CC=C4)C3)[H])C5=CC=CC=C5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JVW-1009 Related Classifications
HY-116968 Related Classifications
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