MAT2A inhibitor 5
Based on 1 Customer Validation
MAT2A inhibitor 5(compound 39) is an orally active, selectivity and blood-brain permeability inhibitor of MAT2A with the IC50 of 11 nM. MAT2A inhibitor 5 inhibits tumor cell growth in vivo.
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- Pureté: 98.80%
- CAS No.: 2957874-18-7
- Formule: C19H14ClFN4O
- Masse moléculaire:368.79
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
>10000 nM
Compound: 39
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Antiproliferative activity against wild type human HCT116 cells assessed as cell viability at incubated for 8 days by multifunctional microplate reader analysis
Antiproliferative activity against wild type human HCT116 cells assessed as cell viability at incubated for 8 days by multifunctional microplate reader analysis
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[PMID: 38818879] |
| HCT-116 | IC50 |
258.8 nM
Compound: 39
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Antiproliferative activity against MTAP-knock out human HCT-116 cells assessed as cell viability at incubated for 8 days by multifunctional microplate reader analysis
Antiproliferative activity against MTAP-knock out human HCT-116 cells assessed as cell viability at incubated for 8 days by multifunctional microplate reader analysis
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[PMID: 38818879] |
Chemical Information
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CAS No. 2957874-18-7
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Appearance Solid
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Masse moléculaire 368.79
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Formule C19H14ClFN4O
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Color White to off-white
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SMILES
O=C1N(C2=CC(Cl)=C(C=C2C3=CN(N=C13)C)F)C4=CC=CN=C4C5CC5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 1.67 mg/mL (4.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7116 mL | 13.5579 mL | 27.1157 mL | 67.7893 mL |
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