MK-8457
MK-8457 is a dual inhibitor of spleen tyrosine kinase (SYK) and zeta-chain-associated protein kinase 70 (ZAP70). MK-8457 can be used for the researches of rheumatoid arthritis, hypertension.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1312518-85-6
- Formule: C24H25F3N4O3S
- Masse moléculaire:506.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
MK-8457 undergoes phase 2 clinical trial investigation for rheumatoid arthritis, terminated due to serious infections and completes phase 1 clinical trial evaluation for blood pressure reduction in hypertensive participants[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1312518-85-6
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Masse moléculaire 506.54
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Formule C24H25F3N4O3S
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SMILES
O[C@]1(C2=NC=C(C3=CC(NC4=NC=CC(C(F)(F)F)=N4)=CC(C)=C3)S2)CC(C)([C@@H](CC1)C(O)=O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MK-8457 Related Classifications
HY-112319A Related Classifications
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