country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-183075

Copy Link Print Information

ND-011458

ND-011458 is an Antibacterial agent, a QcrB inhibitor, and also an inhibitor of cytochrome bcc:aa3 oxidase function. ND-011458 binds to the QcrB subunit of cytochrome bcc:aa3 oxidase. ND-011458 inhibits ATP formation. When used in combination with Clofazimine (HY-B1046), ND-011458 exhibits bactericidal activity against Mycobacterium abscessus. ND-011458 can be used in studies related to Mycobacterium abscessus pulmonary infections.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1648720-01-7
Formule: C₂₈H₂₆ClF₃N₄O₂
Masse moléculaire:542.98

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ND-011458 Chemical Structure

CAS No.: 1648720-01-7

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

ND-011458 potently inhibits the growth of multiple subspecies of the *Mycobacterium abscessus* complex and depletes their intracellular ATP^[1].
ND-011458 directly inhibits the respiration of purified recombinant *Mycobacterium abscessus* cyt-bcc:aa₃ oxidase, confirming that it targets this enzyme complex^[1].
ND-011458 (0.1-20 μM; 3 days, checkerboard assay) exerts an additive effect with Clofazimine to inhibit the growth of *Mycobacterium abscessus* (FIC index = 0.82); their combination (10 μM ND-011458 + 8 μM CFZ) exhibits bactericidal activity, reducing the bacterial load by approximately 1 log within 4 days^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1648720-01-7
Masse moléculaire 542.98
Formule C₂₈H₂₆ClF₃N₄O₂
SMILES

ClC1=CN2C(C(NCC3=CC=C(N4CCC(C5=CC=C(OC(F)(F)F)C=C5)CC4)C=C3)=O)=C(C)N=C2C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Mathiyazakan V, et al. The Mycobacterium abscessus cytochrome bcc:aa₃ oxidase structure paves the way for an agent targeting subunit QcrB. Nat Commun. Published online April 3, 2026. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Obtenir un devis En stock