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Cat. No.: HY-186105

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P7C3-S243

P7C3-S243 is a brain-penetrant P7C3 class of neuroprotective agent. P7C3-S243 augments synthesis of nicotinamide adenine dinucleotide through activation of the metabolic enzyme nicotinamide phosphoribosyltransferase. P7C3-S243 shows potent neuroprotective efficacy in parkinson’s disease mice models. P7C3-S243 can be used for the research of parkinson’s disease.

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CAS No.: 1421622-85-6
Formule: C₂₁H₁₈Br₂FN₃O
Masse moléculaire:507.19

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

P7C3-S243 Chemical Structure

CAS No.: 1421622-85-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Bioz

Activité biologique

Description

In Vivo

P7C3-S243 (10 mg/kg/day; i.p.; pre-administration for 3 days before induction and continuous administration for 7 days after induction) protects against 6-OHDA-induced dopaminergic neuron death, preserves striatal dopamine and metabolite levels, and restores normal motor behavior in a rat model of Parkinson's disease^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Long Evans (adult male, 250-300 g, unilateral stereotactic injection of 6-OHDA into right median forebrain bundle)^[1]
Dosage:

10 mg/kg/day
Administration:

intraperitoneal injection; daily; 7 days (with 3 days of pretreatment before 6-OHDA injection)
Result:

Restored rearing ability, spontaneous locomotor activity, and reduced amphetamine-induced ipsiversive circling.
Increased survival of tyrosine hydroxylase-positive neurons in the ipsilateral substantia nigra pars.
Preserved tyrosine hydroxylase and NeuN colocalization in substantia nigra pars compacta neurons, with survival levels approximating sham-injured rats.
Significantly restored levels of striatal dopamine, DOPAC, and homovanillic acid toward normal sham-injured levels; no effect on striatal serotonin levels.

Chemical Information

CAS No. 1421622-85-6
Masse moléculaire 507.19
Formule C₂₁H₁₈Br₂FN₃O
SMILES

FC(CN1C2=CC=C(C=C2C3=C1C=CC(Br)=C3)Br)CNC4=NC(OC)=CC=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. De Jesús-Cortés H, Miller A D, Britt J K, et al. Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's disease[J]. NPJ Parkinson's disease, 2015, 1(1): 1-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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