POLRMT-IN-2
POLRMT-IN-2 is a potent POLRMT inhibitor. POLRMT-IN-2 exhibits strong antiproliferative activity in MOLM-13 cells, with an IC50 of 1.01 μM. POLRMT-IN-2 disrupts mitochondrial function and induces apoptosis in MOLM-13cells. POLRMT-IN-2 can be used for the study of acute myeloid leukemia(AML).
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- Formule: C34H32N4O5
- Masse moléculaire:576.64
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
POLRMT-IN-2 (Compound 10a) (0-100 μM, 48 h) inhibits POLRMT activity dose-dependently in MOLM-13 cells, with an EC50 value of 2.208 μΜ for ND1 expression suppression[1].
POLRMT-IN-2 (48 h) shows anti-proliferation activity in cells with IC50s of 1.01 μΜ (MOLM-13 cells), 3.24 μΜ (MV4-11 cells) and 14.17 μΜ (HL-60 cells)[1].
POLRMT-IN-2 (5 μM, 48 h) can inhibit the proliferation of MOLM-13 cells, as evidenced by the reduction in EdU-positive cells and decreased Ki67 expression[1].
POLRMT-IN-2 (0-10 μM, 48 h) disrupts mitochondrial function in MOLM-13 cells, as demonstrated by dose-dependent increases in ROS levels, decreases in ATP content, and reduction of mitochondrial membrane potential[1].
POLRMT-IN-2 (0-10 μM, 48 h) induces apoptosis and reduces the expression of both AKT and p-AKTSer473 in MOLM-13 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MOLM 13 cells
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Concentration:5 μM
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Incubation Time:48 h
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Result:Increased the positive areas of tunel staining.
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Cell Line:MOLM 13 cells
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Concentration:0, 2.5, 5, 10 μM
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Incubation Time:48 h
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Result:Increased the expression of apoptosis marker Bax significantly.
Decreased the expression of Bcl-2 was significantly.
Chemical Information
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Masse moléculaire 576.64
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Formule C34H32N4O5
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SMILES
CC1=CC=C(C(C)=C1)C2=CC(OC3=C2C=CC(O[C@@H](C(N4C5CN(C(NC6=CC=CC(C#N)=C6)=O)CC4CC5)=O)C)=C3)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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