Diterpenoids from the Root Bark of Pinus massoniana and Evaluation of Their Phosphodiesterase Type 4D Inhibitory Activity

  • J Nat Prod. 2020 Apr 24;83(4):1229-1237. doi: 10.1021/acs.jnatprod.9b01269.
Yifan Fu  1  2 ,  Xiaoyu Ding  2  3 ,  Xianglei Zhang  2  3 ,  Xingcheng Shao  1  2 ,  Jihui Zhao  2  3 ,  Yechun Xu  2  3 ,  Xiaomin Luo  2  3 ,  Weimin Zhao  1  2
Affiliations
  • 1. Department of Natural Products Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
  • 2. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
  • 3. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.
PMID: 32100544 DOI: 10.1021/acs.jnatprod.9b01269
Abstract

Thirty-two Diterpenoids were obtained from the root bark of Pinus massoniana, and, among them, five compounds (pinmassins A-E) were identified as undescribed analogues. Spectroscopic methods, X-ray single-crystal diffraction analysis, and ECD calculations were applied to establish the structure of the new isolates. Pinmassin D (4) and abieta-8,11,13,15-tetraen-18-oic acid (23) showed moderate phosphodiesterase type 4D (PDE4D) inhibitory effects with IC50 values of 2.8 ± 0.18 and 3.3 ± 0.50 μM, respectively, and their binding modes were investigated by a molecular docking study.

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