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Cat. No.: HY-162569

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Ru-TRZ2

Ru-TRZ2 is a potent ruthenium-based chemotherapeutic agent. Ru-TRZ2 induces apoptosis and necroptosis. Ru-TRZ2 shows antitumor activity.

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Formule: C₄₅H₄₃F₆N₄O₇P₂RuS₂
Masse moléculaire:1092.98

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Ru-TRZ2 Chemical Structure

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Sample (0.1mg)

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(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Bioz

Activité biologique

Description

Ru-TRZ2 is a potent ruthenium-based chemotherapeutic agent. Ru-TRZ2 induces apoptosis and necroptosis. Ru-TRZ2 shows antitumor activity^[1].

In Vitro

Ru-TRZ2 (72 h) induces necroptosis with IC₅₀s of 0.45, 0.24 µM for HCT116, HT29 cells, respectively^[1].
Ru-TRZ2 induces mitochondrial depolarization and apoptotic cell death in HT29 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

HT29 cells
Concentration:

10 μM
Incubation Time:

24 h
Result:

Induced apoptosis and increased the expression of cleaved PARP.

In Vivo

Ru-TRZ2 (5 mg/kg; i.v.; every 2 days for 10 injections) shows anti-tumor activity in HT29 xenograft mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

8-10 weeks, Male nude mice^[1]
Dosage:

5 mg/kg
Administration:

I.v.; every 2 days for 10 injections
Result:

Decreased the tumor weight in HT29 xenograft mice.

Chemical Information

Masse moléculaire 1092.98
Formule C₄₅H₄₃F₆N₄O₇P₂RuS₂
SMILES

FC(F)(F)S(=O)([O-])=O.CN(C(CCC)=O)/N=N/C1=CC=C(C#[N][Ru+2]2([])[P](C3=CC=CC=C3)(C4=CC=CC=C4)CC[P]2(C5=CC=CC=C5)C6=CC=CC=C6)C=C1.FC(F)(F)S(=O)([O-])=O.C7CCCC7
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Gonçalves J, et al. Necroptosis induced by ruthenium (II) complexes as mitochondrial disruptors. Cell Death Discov. 2024 May 28;10(1):261. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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