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Cat. No.: HY-163914

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Telomerase-IN-7

Telomerase-IN-7 (compound 9) is a Telomerase inhibitor with an IC₅₀ of 0.03 μM.

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CAS No.: 444320-44-9
Formule: C₂₄H₃₀N₂O₆
Masse moléculaire:442.50

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Telomerase-IN-7 Chemical Structure

CAS No.: 444320-44-9

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Bioz

Activité biologique

Description

Telomerase-IN-7 (compound 9) is a Telomerase inhibitor with an IC₅₀ of 0.03 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CT26	IC₅₀	26.892 μM Compound: 9	Antiproliferative activity against mouse CT26 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay Antiproliferative activity against mouse CT26 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay	[PMID: 39140071]
GES1	IC₅₀	>1000 μM Compound: 9	Cytotoxicity against human GES1 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay Cytotoxicity against human GES1 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay	[PMID: 39140071]
HL-60	IC₅₀	155.651 μM Compound: 9	Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth measured after 96 hrs by CCK-8 assay	[PMID: 39140071]

Chemical Information

CAS No. 444320-44-9
Masse moléculaire 442.50
Formule C₂₄H₃₀N₂O₆
SMILES

O=C(C(/C1=C/C2=CC=C(C=C2)OCC(NC(C)C)=O)=C(C)N(CC3OCCC3)C1=O)OC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zuo H, et al. Small Molecules Blocking the Assembly of TCAB1 and Telomerase Complexes: Lead Discovery and Biological Activity[J]. ACS Medicinal Chemistry Letters, 2024.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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